Mouse Anti-GARS Recombinant Antibody (VS3-FY2716)
CAT#: VS3-FY2716
This anti-GARS antibody is a mouse recombinant monoclonal antibody that is specifically engineered to target GARS. The calculated molecular weight of the antigen is 83.2 kDa. It shows capability of cross-reacting with human, mouse and rat. This monoclonal antibody is potential for conducting research on Neuronopathy, Distal Hereditary Motor, Autosomal Dominant 5 and Spinal Muscular Atrophy, Infantile, James Type. This monoclonal antibody can be used in Western Blot, Immunocytochemistry.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17896/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19097/43764_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19097/43764_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19097/43764_A_9_4.jpg
Normal Tissue
Figure 5 Pancreas
Exocrine glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Pancreatic endocrine cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19097/43764_A_3_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19097/43764_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19097/43764_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19097/43764_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000106105-GARS
❮
❯
| Sub Cat | Application | Application Notes | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS3-FY2774 | WB, ICC |
Western Blot: 1/500-1/2000 Immunocytochemistry: 1/10-1/25 |
||||||
| VS3-FY2717 | WB, FC |
Western Blot: 1/500-1/2000 Flow cytometry: 1/10-1/25 |
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Glycyl-TRNA synthetase of human, mouse and rat origins
- Species Reactivity
- Human, Mouse, Rat
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 83.2 kDa.
- Related Disease
- Neuronopathy, Distal Hereditary Motor, Autosomal Dominant 5 and Spinal Muscular Atrophy, Infantile, James Type
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Glycyl-TRNA Synthetase; Diadenosine Tetraphosphate Synthetase; Charcot-Marie-Tooth Neuropathy 2D; AP-4-A Synthetase; EC 6.1.1.14; GlyRS; Charcot-Marie-Tooth Neuropathy, Neuronal Type, D; Glycine--TRNA Ligase
- Gene ID
- 2617
- UniProt ID
- P41250
- Sequence Similarities
- Belongs to the class-II aminoacyl-tRNA synthetase family.
- Cellular Localization
- Cytoplasm
Cell projection, axon
Secreted
Secreted, extracellular exosome
- Post Translation Modifications
- Ubiquitination at Lys108, Lys197, Lys309, Lys318, Lys379, Lys419, and Lys563
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001303701.1; NP_002038.2
- Function
- Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "GARS"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3126z | Mouse Anti-GARS Recombinant Antibody (clone 23D3) | WB, IP, IF, ELISA | Mouse IgG2b, κ |
| MRO-0634-CN | Rabbit Anti-GARS Recombinant Antibody (clone CBACN-236) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1399 | Hi-Affi™ Rabbit Anti-GARS Recombinant Antibody (clone DS1399AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY899 | Anti-GARS Immunohistochemistry Kit | IHC |
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