Anti-GATA3 (clone W24V23) Recombinant Antibody Coupled Liposome (VS-1024-FY24)
CAT#: VS-1024-FY24
The lipid vesicles that are conjugated to anti-CD28 antibodies have the potential to elicit a nonspecific activation of autoreactive T cells, raising concerns about their impact on immune homeostasis. However, the limited ability of these vesicles to target tumor cells effectively could hinder their therapeutic efficacy in activating cytotoxic T cell responses against cancers. Consequently, further studies are essential to explore the intricate relationship between this antibody binding, immune regulation, and the overall anti-cancer properties of the lipid vesicles in various experimental models.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29730/295_B8_1_selected.jpg
Normal Tissue
Figure 2 High expression in placenta.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16217/140542_A_1_7_val_selected.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16217/140542_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16217/140542_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Collecting ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Distal tubules Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16217/140542_A_7_5.jpg
Normal Tissue
Figure 6 Breast
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16217/140542_B_3_4.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (BEWO, MCF7, RT4, SH-SY5Y, T-47d)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107485-GATA3
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More Infomation
Specifications
- Potential Clinical Applications
- Potentially kill T cell lines (e.g. CCRFCEM)
Product Composition
- Clone
- W24V23
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant antibody derived from mice, specifically designed to target the transcription factor GATA-3. GATA-3 plays a crucial role in various biological processes, including the regulation of immune responses and the development of certain cell types. This high-affinity antibody has been engineered to provide consistent and reliable performance in a variety of experimental applications, making it an invaluable tool for researchers studying cellular differentiation, T-helper cell development, and other immune-related functions.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- GATA3
- Introduction
- This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.
- Alternative Names
- GATA Binding Protein 3; GATA-Binding Factor 3; Trans-Acting T-Cell-Specific Transcription Factor GATA-3; GATA-Binding Protein 3; HDRS; HDR
- Full Name
- GATA Binding Protein 3
- Gene ID
- 2625
- UniProt ID
- P23771
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity).
- Protein Refseq
- NP_001002295.1; NP_002042.1
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Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2742 | Anti-GATA3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2743 | Anti-Mouse GATA3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2744 | Anti-Rat GATA3 Immunohistochemistry Kit | IHC |
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