AbPlus™ Anti-GNAS Magnetic Beads (VS-0724-YC1559)
CAT#: VS-0724-YC1559
The AbPlus Anti-GNAS Magnetic Beads (VS-0724-YC1559) is an innovative affinity resin which is bound with anti-GNAS specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of GNAS protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10337/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in islet cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18122/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human fallopian tube
Immunohistochemical staining of human fallopian tube shows distinct positivity in cilia.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28386/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27478/59437_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27478/59437_A_8_3.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000087460-GNAS
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-GNAS specific antibody
- Target
- GNAS
- Immunogen
- Synthetic peptide corresponding to the N-terminus of the human GNAS.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
- Alternative Names
- GNAS Complex Locus; Guanine Nucleotide Binding Protein (G Protein), Alpha Stimulating Activity Polypeptide 1; Adenylate Cyclase-Stimulating G Alpha Protein; Alternative Gene Product Encoded By XL-Exon; Extra Large Alphas Protein; G Protein Subunit Alpha S; Secretogranin VI; GNAS1; GSP; Guanine Nucleotide-Binding Protein G(S) Subunit Alpha Isoforms XLas; Guanine Nucleotide Regulatory Protein; Neuroendocrine Secretory Protein; Protein SCG6 (Secretogranin VI); Protein ALEX;
- Gene ID
- 2778
- UniProt ID
- O95467
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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