AbPlus™ Anti-GNAS Magnetic Beads (VS-0724-YC1559) (CAT#: VS-0724-YC1559)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magnetic bead

• Bead Ligand
• Anti-GNAS specific antibody

• Target
• GNAS

• Immunogen
• Synthetic peptide corresponding to the N-terminus of the human GNAS.

• Target Species
• Human

• Bead Capacity
• 40 mg/mL

• Bead size
• 25 μm

• Format
• Suspension

• Concentration
• 2 mg/mL

• Buffer
• PBS, pH 7.4

• Preservative
• 0.1% Sodium azide

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]

• Alternative Names
• GNAS Complex Locus; Guanine Nucleotide Binding Protein (G Protein), Alpha Stimulating Activity Polypeptide 1; Adenylate Cyclase-Stimulating G Alpha Protein; Alternative Gene Product Encoded By XL-Exon; Extra Large Alphas Protein; G Protein Subunit Alpha S; Secretogranin VI; GNAS1; GSP; Guanine Nucleotide-Binding Protein G(S) Subunit Alpha Isoforms XLas; Guanine Nucleotide Regulatory Protein; Neuroendocrine Secretory Protein; Protein SCG6 (Secretogranin VI); Protein ALEX;

• Gene ID
• 2778

• UniProt ID
• O95467

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