Rabbit Anti-GRK6 Recombinant Antibody (clone R07-3E4) (CAT#: VS3-FY2007)

The R07-3E4 recombinant monoclonal antibody specifically recognizes human GRK6. It cross-reacts with mouse. This GRK6 antibody was verified by western blot analysis of GRK6 in mouse spleen lysates. Western blot demonstrated that R07-3E4 recognized a target protein with a molecular weight of 66 kDa.

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  • Tested Data
  • Gene Expression
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  • MSDS
  • COA
WB

Figure 1 Anti-GRK6 Antibody (VS3-FY2007) in WB.

Figure 1 Anti-GRK6 Antibody (VS3-FY2007) in WB.

The GRK6 expression in mouse spleen lysates were detected using the anti-GRK6 by western blot assay.


Specifications

  • Immunogen
  • Synthetic peptide of human GRK6
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human and Mouse GRK6
  • Species Reactivity
  • Human, Mouse
  • Clone
  • R07-3E4
  • Applications
  • Western Blot
  • MW
  • The calculated weight of the target protein is approximately 66 kDa, while the observed molecular weight stands at 66 kDa.
  • Related Disease
  • Whim Syndrome 1 and Huntington Disease

Product Property

  • Purification
  • Affinity Purified
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
  • Preservative
  • 0.01% Sodium azide
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Western Blot: 1/500-1/1000

Target

  • Alternative Names
  • G Protein-Coupled Receptor Kinase 6; EC 2.7.11.16; GPRK6; G Protein-Coupled Receptor Kinase GRK6; EC 2.7.11
  • Sequence Similarities
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
  • Cellular Localization
  • Membrane
  • Post Translation Modifications
  • It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. (P43250-GRK6_HUMAN)
    Ubiquitination at Lys343 and Lys358 (NX_P43250 [NX_P43250-1])
    Modification sites at PhosphoSitePlus (P43250)
  • Function
  • Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity).

Recommended Products

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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CAT Product Name Application Type
MOB-419 Recombinant Anti-human GRK6 Antibody WB, Neut, FuncS IgG
MHH-419 Recombinant Human Anti-human GRK6 Antibody IP, RIA, FuncS IgG
MOB-2439MZ Recombinant Mouse Anti-Human GRK6 Antibody WB Mouse antibody

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