Rabbit Anti-GRK6 Recombinant Antibody (clone R07-3E4) (CAT#: VS3-FY2007)
The R07-3E4 recombinant monoclonal antibody specifically recognizes human GRK6. It cross-reacts with mouse. This GRK6 antibody was verified by western blot analysis of GRK6 in mouse spleen lysates. Western blot demonstrated that R07-3E4 recognized a target protein with a molecular weight of 66 kDa.
Specific Inquiry
WB
Figure 1 Anti-GRK6 Antibody (VS3-FY2007) in WB.
The GRK6 expression in mouse spleen lysates were detected using the anti-GRK6 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human GRK6
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse GRK6
- Species Reactivity
- Human, Mouse
- Clone
- R07-3E4
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 66 kDa, while the observed molecular weight stands at 66 kDa.
- Related Disease
- Whim Syndrome 1 and Huntington Disease
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- G Protein-Coupled Receptor Kinase 6; EC 2.7.11.16; GPRK6; G Protein-Coupled Receptor Kinase GRK6; EC 2.7.11
- Gene ID
- 2870
- UniProt ID
- P43250
- Sequence Similarities
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
- Cellular Localization
- Membrane
- Post Translation Modifications
- It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. (P43250-GRK6_HUMAN)
Ubiquitination at Lys343 and Lys358 (NX_P43250 [NX_P43250-1])
Modification sites at PhosphoSitePlus (P43250)
- Protein Refseq
- XP_006714921.1; XP_006714922.1; XP_011532840.1; XP_047273082.1; XP_054208434.1
- Function
- Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "GRK6"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-419 | Recombinant Anti-human GRK6 Antibody | WB, Neut, FuncS | IgG |
| MHH-419 | Recombinant Human Anti-human GRK6 Antibody | IP, RIA, FuncS | IgG |
| MOB-2439MZ | Recombinant Mouse Anti-Human GRK6 Antibody | WB | Mouse antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-419-F(E) | Recombinant Anti-human GRK6 Antibody Fab Fragment | IP, IF, FuncS | Fab |
| MHH-419-F(E) | Recombinant Human Anti-human GRK6 Antibody Fab Fragment | FC, WB, FuncS | Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-419-S(P) | Recombinant Anti-human GRK6 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| MHH-419-S(P) | Recombinant Human Anti-human GRK6 Antibody scFv Fragment | Neut, IF, FuncS | scFv |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1516 | Rabbit Anti-GRK6 Recombinant Antibody (clone DS1516AB) | WB, ICC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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