Rabbit Anti-HNRNPK Recombinant Antibody (VS13-YC543) (CAT#: VS13-YC543)

• Immunogen
• Recombinant human hnRNP K.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human HNRNPK

• Species Reactivity
• Human

• Applications
• IHC-P

• Conjugate
• NONE

• Clonality
• Monoclonal

• Purification
• Affinity Chromatography purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS (pH 7.2) containing 50% Glycerol and 0.5% BSA.

• Preservative
• 0.02% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Immunohistochemistry (IHC): 1/100-1/200

• Alternative Names
• Heterogeneous Nuclear Ribonucleoprotein K; Transformation Upregulated Nuclear Protein; HNRPK; TUNP; Transformation Up-Regulated Nuclear Protein; DC-Stretch Binding Protein; HnRNP K; AUKS; CSBP;

• Gene ID
• 3190

• UniProt ID
• P61978

• Long Name
• Heterogeneous Nuclear Ribonucleoprotein K

• Cellular Localization
• Cell junction; Cell projection; Cytoplasm; Nucleus; Spliceosome

• Protein Refseq
• NP_001305115.1; NP_001305116.1; NP_001305117.1

• Function
• One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity).
  As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841).

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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