Mouse Anti-HSP90AA1 Recombinant Antibody (VS3-FY2738) (CAT#: VS3-FY2738)
The anti-HSP90AA1 antibody is a mouse recombinant monoclonal antibody, which has been intricately crafted to target the human Hsp90 alpha protein. It exhibits cross-reactivity with mouse, rat, and monkey. This monoclonal antibody proves valuable in disease research related to Lissencephaly 7, accompanied by cerebellar hypoplasia (LIS7).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/if_selected.jpg
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/ihc_selected.jpg
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/ihc_selected.jpg
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/673_C12_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/673_C12_1_blue_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/667_C12_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/667_C12_1_blue_red_green.jpg
Figure 5 Testis
(Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/5779_A_5_6.jpg
(Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2058/5779_A_5_6.jpg
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000080824-HSP90AA1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000080824-HSP90AA1
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Heat shock protein 90 alpha family class A member 1 of human, mouse, rat and monkey origins
- Species Reactivity
- Human, Mouse, Rat, Monkey
- Applications
- WB
- Conjugate
- Unconjugated, FITC
- Related Disease
- Candidiasis; Herpes Simplex
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Heat Shock Protein 90 Alpha Family Class A Member 1; Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1; Lipopolysaccharide-Associated Protein 2; Heat Shock 90kDa Protein 1, Alpha; Renal Carcinoma Antigen NY-REN-38; Heat Shock 90kD Protein 1, Alpha; LPS-Associated Protein 2; Heat Shock 86 KDa; HSP 86; HSP90A; HSPC1; HSPCA; HSP86; LAP-2; Heat Shock Protein 90kDa Alpha Family Class A Member 1; Epididymis Secretory Sperm Binding Protein Li 65p
- Gene ID
- 3320
- UniProt ID
- P07900
- Cellular Localization
- Nucleus, Cytoplasm, Melanosome, Cell membrane, Mitochondrion
- Post Translation Modifications
- Glycosylation at Asn397
Ubiquitination at Lys58, Lys84, Lys224, Lys314, Lys419, Lys436, Lys443, Lys446, Lys478, Lys489, Lys499, Lys513, and Lys632
Modification sites at PhosphoSitePlus
Glycosylation from Gly
Glycosylation from GlyGen 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011535020.1; XP_054231954.1
- Function
- Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.
Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity.
This cycle probably induces conformational changes in the client proteins, thereby causing their activation.
Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0881CT | Recombinant Mouse anti-Human HSP90AA1 Monoclonal antibody (5G20) | ELISA, IHC-P, WB | |
| MRO-1948-CN | Rabbit Anti-HSP90AA1 Polyclonal Antibody (MRO-1948-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-WK1380 | Mouse Anti-HSP90AA1 Recombinant Antibody (clone 1H4) | WB, IHC-P | Mouse IgG |
| VS3-WK1381 | Mouse Anti-HSP90AA1 Recombinant Antibody (VS3-WK1381) | WB, IHC-P | Mouse IgG |
| VS13-YC554 | Rabbit Anti-HSP90AA1 Recombinant Antibody (VS13-YC554) | WB, ICC, IF, IHC-P | Rabbit IgG |
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