SmartAb™ Recombinant Anti-IL17C pH-dependent Antibody (VS-0825-YC176)
CAT#: VS-0825-YC176
The anti-IL17C pH-dependent antibody (VS-0825-YC176) targets human Interleukin 17C (IL-17C) in a pH-dependent manner, with its affinity remaining high at neutral pH but weakening at a lower pH, such as within the acidic environment of endosomes. The anti-IL17C acid-switched antibody was engineered by incorporating histidine residues into its variable regions. The introduction of histidine substitutions within its Complementarity-Determining Regions (CDRs) enables pH-responsive antigen binding, which leads to enhanced IL17C clearance. The antibody operates in a cyclical manner, binding IL-17C in the extracellular fluid and releasing it in acidified endosomes. Human Interleukin 17C, or IL-17C, is a cytokine that is involved in mucosal immunity and is a key player in inflammatory diseases of the gut. It is a member of the IL-17 family and is produced by epithelial cells.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows moderate granular cytoplasmic positivity in germinal center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65051/ihc_selected.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65051/150078_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65051/150078_A_5_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65051/150078_A_8_8.jpg
Normal Tissue
Figure 5 Tonsil
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65051/150078_A_6_8.jpg
❮
❯
Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- IgG2 (combining the mouse antibody's antigen-binding variable regions with a human IgG2 constant region)
- Specificity
- Human Interleukin 17C
- Species Reactivity
- Human
- Applications
- ELISA, Block
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0825-YC176. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "IL17c"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-090ZJ | Human Anti-IL17C Recombinant Antibody (TAB-090ZJ) | ELISA, Block | Chimeric (Mouse/Human) IgG2 |
| TAB-090ZJ-S(P) | Human Anti-IL17C Recombinant Antibody; scFv Fragment (TAB-090ZJ-S(P)) | ELISA, Block | Human scFv |
| TAB-091ZJ-S(P) | Human Anti-IL17C Recombinant Antibody; scFv Fragment (TAB-091ZJ-S(P)) | ELISA, Block | Human scFv |
| TAB-090ZJ-F(E) | Human Anti-IL17C Recombinant Antibody; Fab Fragment (TAB-090ZJ-F(E)) | ELISA, Block | Chimeric (Mouse/Human) Fab |
| TAB-091ZJ-F(E) | Human Anti-IL17C Recombinant Antibody; Fab Fragment (TAB-091ZJ-F(E)) | ELISA, Block | Chimeric (Mouse/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0229CT | Recombinant Mouse anti-Human IL17C Monoclonal antibody (NN0486-0Q42) | WB | |
| HPAB-M0536-YC | Human Anti-IL17C Recombinant Antibody (HPAB-M0536-YC) | ELISA, FuncS | Human IgG1 |
| HPAB-M0537-YC | Human Anti-IL17C Recombinant Antibody (HPAB-M0537-YC) | ELISA, FuncS | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0536-YC-S(P) | Human Anti-IL17C Recombinant Antibody; scFv Fragment (HPAB-M0536-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-M0537-YC-S(P) | Human Anti-IL17C Recombinant Antibody; scFv Fragment (HPAB-M0537-YC-S(P)) | ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0536-YC-F(E) | Human Anti-IL17C Recombinant Antibody; Fab Fragment (HPAB-M0536-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-M0537-YC-F(E) | Human Anti-IL17C Recombinant Antibody; Fab Fragment (HPAB-M0537-YC-F(E)) | ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3493 | Anti-IL17C Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC168 | Recombinant Anti-IL17C Eliminating Antibody, pH-Sensitive (VS-0625-YC168) | Antigen-Sweeping In Vivo. | Human IgG2 |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: ELISA, FuncS, IHC, IF, FC, ADCC
Application: ELISA
Application: Neut, FC, IHC-Fr, IP, BA
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FC, Inhib, FuncS
Application: Neut, ELISA, IF, IP, FuncS, FC
-3.jpg)
Application: IB, FC, ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
