Rabbit Anti-IL18BP Recombinant Antibody (clone R31-4Z-6)
CAT#: VS3-FY2188
Clone R31-4Z-6 is a rabbit recombinant monoclonal antibody that detects human IL18BP. It cross-reacts with rat. For detection of human IL18BP using WB and IHC, please refer to clone R31-4Z-6. Western blot demonstrated that R31-4Z-6 recognized a target protein with a molecular weight of 21 kDa.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25980/663_F4_4_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41061/137724_B_8_5.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41061/137724_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41061/137724_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137496-IL18BP
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat IL18BP
- Species Reactivity
- Human, Rat
- Clone
- R31-4Z-6
- Applications
- Western Blot, Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
- MW
- The calculated weight of the target protein is approximately 21kDa, while the observed molecular weight stands at 40kDa.
- Related Disease
- Crohn's disease
Product Property
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4), 150 mM NaCl, 50% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/100-1/200
Target
- Alternative Names
- Interleukin 18 Binding Protein
- Gene ID
- 10068
- UniProt ID
- O95998
- Cellular Localization
- Secreted
- Post Translation Modifications
- N- and O-glycosylated.
O-glycosylated with core 1-like and core 2-like glycans.
O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor).
N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4.
(O95998-I18BP_HUMAN)
Glycosylation at Ser46, Thr47, Ser53, Asn79, Asn94, Asn103, and Asn147 (NX_O95998 [NX_O95998-2])
Modification sites at PhosphoSitePlus (O95998)
Glycosylation from GlyConnect I18BP_HUMAN (669)
Glycosylation from GlyGen (O95998) 8 sites, 6 N-linked glycans (2 sites), 6 O-linked glycans (4 sites)
- Protein Refseq
- XP_016872548.1; XP_016872550.1; XP_016872552.1; XP_024304071.1; XP_024304072.1
- Function
- Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "IL18BP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-205CT | Mouse Anti-IL18BP Recombinant Antibody (TAB-205CT) | ELISA | Mouse IgG |
| TAB-205CT-S(P) | Mouse Anti-IL18BP Recombinant Antibody; scFv Fragment (TAB-205CT-S(P)) | ELISA | Mouse scFv |
| TAB-206CT-S(P) | Mouse Anti-IL18BP Recombinant Antibody; scFv Fragment (TAB-206CT-S(P)) | ELISA | Mouse scFv |
| TAB-205CT-F(E) | Mouse Anti-IL18BP Recombinant Antibody; Fab Fragment (TAB-205CT-F(E)) | ELISA | Mouse Fab |
| TAB-206CT-F(E) | Mouse Anti-IL18BP Recombinant Antibody; Fab Fragment (TAB-206CT-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0233CT | Recombinant Mouse anti-Human IL18BP Monoclonal antibody (NN0480-20H47) | WB | |
| VS3-QX593 | Mouse Anti-IL18BP Recombinant Antibody (clone 5C7-D2-G4-B6) | WB | Mouse IgG2b |
| VS4-WK249 | Mouse Anti-IL18BP Recombinant Antibody (VS4-WK249) | ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1244CQ | Mouse Anti-IL18BP Recombinant Antibody (clone CBL078) | Neut, WB | Mouse IgG1 |
| NEUT-1245CQ | Mouse Anti-IL18BP Recombinant Antibody (clone CBL545) | Neut | Mouse IgG1 |
| NEUT-1246CQ | Mouse Anti-IL18BP Recombinant Antibody (clone 10G36) | Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1795 | Rabbit Anti-IL18BP Recombinant Antibody (clone DS1795AB) | ELISA, WB | Rabbit IgG |
| MOR-4249 | Rabbit Anti-IL18BP Recombinant Antibody (clone SI328DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY3 | Mouse Anti-IL18BP scFv-Fc Chimera (VS-0425-FY3) | IA | Mouse IgG1, scFv-Fc |
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