Mouse Anti-KBTBD8 Recombinant Antibody (clone 7G8A6)
CAT#: VS7-0425-WR181
This product is a mouse IgG1 antibody that binds to human KBTBD8. The antibody 7G8A6 recognizes specific amino acid domain of human KBTBD8 (AA: 264-464). It can be used for WB and FC assays.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in few non-germinal center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41285/89085_A_7_8_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong positivity in germinal center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69190/156347_A_6_8_selected.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69190/156347_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69190/156347_A_9_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69190/156347_A_5_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69190/156347_A_9_8.jpg
Normal Tissue
Figure 7 Tonsil
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Squamous epithelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69190/156347_A_6_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (Daudi, Karpas-707, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000163376-KBTBD8
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Specifications
- Immunogen
- Recombinant human KBTBD8 (AA: 264-464) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human KBTBD8
- Species Reactivity
- Human
- Clone
- 7G8A6
- Applications
- WB, FC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- TAKRP; TA-KRP
- Gene ID
- 84541
- UniProt ID
- Q8NFY9
- Long Name
- Kelch Repeat And BTB Domain Containing 8
- Cellular Localization
- Cytoplasm; Cytoskeleton; Golgi apparatus
- Protein Refseq
- NP_115894.2
- Function
- Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification.; The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "KBTBD8"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1911 | Hi-Affi™ Recombinant Rabbit Anti-KBTBD8 Monoclonal Antibody (DS1911AB) | FC, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX628 | Mouse Anti-KBTBD8 Recombinant Antibody (clone 2H12B8) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-QX629 | Mouse Anti-KBTBD8 Recombinant Antibody (clone 5B5-F11-A8) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-QX630 | Mouse Anti-KBTBD8 Recombinant Antibody (clone 6G-8A) | WB, FC | Mouse IgG1 |
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