Anti-KRT14 (clone W24V63) Recombinant Antibody Coupled Liposome (VS-1024-FY64)
CAT#: VS-1024-FY64
Antibody-conjugated liposomes targeting KRT14 may have potential in the treatment of breast cancer, as studies suggest that KRT14-positive cells may play a "leader cell" role in tumor invasion. These antibody-conjugated liposomes can specifically target tumor cells, thereby enhancing therapeutic efficacy and potentially providing more opportunities for clinical applications.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to intermediate filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23040/1660_C10_5_selected.jpg
Normal Tissue
Figure 2 Skin 1
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23040/51237_B_9_1_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23040/51237_B_8_5.jpg
Normal Tissue
Figure 4 Skin
Keratinocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Langerhans Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Melanocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/134/1050_B_7_1.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1, U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186847-KRT14
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More Infomation
Specifications
- Potential Clinical Applications
- Breast cancer
Product Composition
- Clone
- W24V63
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The recombinant mouse antibody exhibits a strong and specific binding affinity for human keratin 14 (KRT14). This ability to selectively recognize and bind to KRT14 is significant, as KRT14 plays a crucial role in the structural integrity of epithelial tissues.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- KRT14
- Introduction
- This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11.
- Alternative Names
- Keratin 14; Keratin 14, Type I; K14; Keratin 14 (Epidermolysis Bullosa Simplex, Dowling-Meara, Koebner); Epidermolysis Bullosa Simplex, Dowling-Meara, Koebner; Keratin, Type I Cytoskeletal 14; Cytokeratin 14; Cytokeratin-14
- Full Name
- Keratin 14
- Gene ID
- 3861
- UniProt ID
- P02533
- Sequence Similarities
- Belongs to the intermediate filament family.
- Cellular Localization
- Cytoplasm, Intermediate filament, Keratin, Nucleus
- Post Translation Modifications
- A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.
Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex.
- Protein Refseq
- NP_000517.2
- Function
- The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
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Datasheet
MSDS
COA
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See other products for "KRT14"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1481z | Mouse Anti-KRT14 Recombinant Antibody (clone 25C3) | ICC, IF, IHC | Mouse IgG3 |
| MOB-0538CT | Recombinant Mouse anti-Human KRT14 Monoclonal antibody (DLC2) | ICC, IF, IHC-Fr, IHC-P, WB | |
| MRO-0436-CN | Recombinant Rabbit Anti-KRT14 Monoclonal Antibody (CBACN-176) | WB, IF, IHC | Rabbit IgG |
| ZG-0234J | Mouse Anti-KRT14 Recombinant Antibody (ZG-0234J) | IHC-P, IF | Mouse IgG |
| ZG-0235J | Mouse Anti-KRT14 Recombinant Antibody (ZG-0235J) | IHC-P, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-1120MZ | Chicken Anti-Keratin 14 Polyclonal IgY | IHC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1978 | Hi-Affi™ Recombinant Rabbit Anti-KRT14 Monoclonal Antibody (DS1978AB) | IHC-P, IHC-Fr | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1380 | AbPlus™ Anti-KRT14 Magnetic Beads (VS-0724-YC1380) | IP, Protein Purification | |
| VS-0724-YC1431 | AbPlus™ Anti-Krt14 Magnetic Beads (VS-0724-YC1431) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1209 | Anti-KRT14 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3843 | Anti-Mouse KRT14 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3842 | Anti-Human KRT14 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3844 | Anti-Rat KRT14 Immunohistochemistry Kit | IHC |
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