Mouse Anti-LEP Recombinant Antibody (VS3-FY2786) (CAT#: VS3-FY2786)
The anti-LEP antibody is a mouse recombinant monoclonal antibody, which has been intricately crafted to target the human Leptin protein. This monoclonal antibody proves valuable in disease research related to Leptin Deficiency Or Dysfunction and Overnutrition. The optimal dilution for this antibody is ELISA (1/1000-1/10000).
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Normal Tissue
RNA Expression
Figure 1 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10490/32980_A_5_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10490/32980_A_5_6.jpg
Figure 2 RNA cell line category: Cell line enhanced (BEWO, SuSa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000174697-LEP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000174697-LEP
Figure 2 RNA cell line category: Cell line enhanced (BEWO, SuSa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000174697-LEP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000174697-LEP
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human LEP
- Species Reactivity
- Human
- Applications
- ELISA
- Conjugate
- Unconjugated, FITC
- Related Disease
- Leptin Deficiency Or Dysfunction and Overnutrition
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- ELISA: 1/1000-1/10000
Target
- Alternative Names
- LEP; LEPD; OB; OBS; leptin
- Gene ID
- 3952
- UniProt ID
- P41159
- Sequence Similarities
- Belongs to the leptin family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (P41159)
Modification sites at neXtProt
- Protein Refseq
- XP_054214181.1; NP_000221.1
- Function
- Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:17344214).
May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (PubMed:18242580).
Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs).
Recommended Products
Secondary Antibody
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1017 | Recombinant Mouse Anti-Human LEP Antibody Fab Fragment | LMNX, ELISA | Fab |
| PFBL-259 | Mouse Anti-LEP Recombinant Antibody (clone 9F8); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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