Mouse Anti-LEP Recombinant Antibody (VS3-FY2786) (CAT#: VS3-FY2786)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human LEP

• Species Reactivity
• Human

• Applications
• ELISA

• Conjugate
• Unconjugated, FITC

• Related Disease
• Leptin Deficiency Or Dysfunction and Overnutrition

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• ELISA: 1/1000-1/10000

• Alternative Names
• LEP; LEPD; OB; OBS; leptin

• Gene ID
• 3952

• UniProt ID
• P41159

• Sequence Similarities
• Belongs to the leptin family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Modification sites at PhosphoSitePlus (P41159)
  Modification sites at neXtProt

• Protein Refseq
• XP_054214181.1; NP_000221.1

• Function
• Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:17344214).
  May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (PubMed:18242580).
  Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs).

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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