PTM™ Rabbit Anti-MAPT (pSer404) Recombinant Antibody (VS13-YC705)
CAT#: VS13-YC705
The PTM™ Rabbit Anti-MAPT (pSer404) Recombinant Antibody is a post-translational modification (PTM) antibody specific for the phosphorylated MAPT (Ser404) of human and rat. Phosphorylation of MAPT (microtubule-associated protein tau) at serine 404, located within the repeat domain, is associated with tau hyperphosphorylation and the formation of neurofibrillary tangles (NFTs). These are key indicators of Alzheimer's disease (AD) and other tauopathies. The anti-MAPT (pSer404) antibody can be used for Western blot (1/500-1/1000).
Specifications
- Immunogen
- Synthetic phosphopeptide of human tau (pSer404).
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- The phosphorylated MAPT (Ser404) of human and rat.
- Species Reactivity
- Human, Rat
- Applications
- WB
- Conjugate
- NONE
- Related Disease
- Alzheimer's disease, Pick's disease
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Target
- Alternative Names
- Microtubule Associated Protein Tau; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Protein Phosphatase 1, Regulatory Subunit 103; Neurofibrillary Tangle Protein; Paired Helical Filament-Tau; PHF-Tau; MAPTL; MTBT1; TAU;
- Gene ID
- 4137
- UniProt ID
- P10636
- Long Name
- Microtubule Associated Protein Tau
- Cellular Localization
- Cell membrane; Cell projection; Cytoplasm; Cytoskeleton; Membrane; Microtubule; Secreted
- Post Translation Modifications
- Phosphorylated
- Protein Refseq
- NP_001116538.2; NP_001116539.1; NP_001190181.1
- Function
- Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311).
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270).
Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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