Rabbit Anti-MLKL Recombinant Antibody (VS13-YC732) (CAT#: VS13-YC732)
The Rabbit Anti-MLKL Recombinant Antibody is specific for human and mouse MLKL. MLKL is part of the kinase superfamily involved in TNF-induced necroptosis, interacting with RIP3. Its high levels interlink with inflammatory diseases like bowel disease, with spliced variants described. The anti-MLKL antibody can be used for Western blot (1/1000), Immunohistochemistry-paraffin (1/50).
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HUVEC TERT2
(Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78638/1751_F6_8_cr57fd37317cd94_selected.jpg
(Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78638/1751_F6_8_cr57fd37317cd94_selected.jpg
Figure 2 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168404-MLKL
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168404-MLKL
Specifications
- Immunogen
- Recombinant human MLKL, aa 333-471.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse MLKL
- Species Reactivity
- Human, Mouse
- Applications
- WB, IHC-P
- Conjugate
- NONE
- Related Disease
- Inflammatory bowel disease
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000
Immunohistochemistry-paraffin (IHC-P): 1/50
Target
- Alternative Names
- Mixed Lineage Kinase Domain Like Pseudokinase; HMLKL; Mixed Lineage Kinase Domain-Like Protein; Mixed Lineage Kinase Domain-Like;
- Gene ID
- 197259
- UniProt ID
- Q8NB16
- Long Name
- Mixed Lineage Kinase Domain Like Pseudokinase
- Cellular Localization
- Cytoplasm; Cell membrane; Golgi apparatus
- Protein Refseq
- XP_011521238.1; XP_005255891.1
- Function
- Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, 22265414, 22421439, 24316671).
Does not have protein kinase activity (PubMed:22265413, 22265414, 22421439, 24316671).
Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage.
Recommended Products
Secondary Antibody
Isotype Control
Related Resources
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "MLKL"
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1006-CN | Recombinant Rabbit Anti-MLKL Monoclonal Antibody (CBACN-374) | WB, IHC | Rabbit IgG |
| MRO-2347-CN | Recombinant Rabbit Anti-MLKL (phosphorylated Ser345) Monoclonal Antibody (JM92-37) | WB, IHC, IP | Rabbit IgG |
| VS3-WK1063 | Rabbit Anti-MLKL Recombinant Antibody (VS3-WK1063) | WB, IHC, IF | Rabbit IgG |
| VS3-WK2174 | Rabbit Anti-MLKL (pS358) Recombinant Antibody (clone R02-2I5) | WB, IHC-P | Rabbit IgG |
| VS3-WK2192 | Mouse Anti-MLKL (pS358) Recombinant Antibody (VS3-WK2192) | IF, ICC, IHC-P | Mouse IgG |
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