Rabbit Anti-MLKL Recombinant Antibody (VS13-YC732) (CAT#: VS13-YC732)

• Immunogen
• Recombinant human MLKL, aa 333-471.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Mouse MLKL

• Species Reactivity
• Human, Mouse

• Applications
• WB, IHC-P

• Conjugate
• NONE

• Related Disease
• Inflammatory bowel disease

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.

• Preservative
• 0.05% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/1000
  Immunohistochemistry-paraffin (IHC-P): 1/50

• Alternative Names
• Mixed Lineage Kinase Domain Like Pseudokinase; HMLKL; Mixed Lineage Kinase Domain-Like Protein; Mixed Lineage Kinase Domain-Like;

• Gene ID
• 197259

• UniProt ID
• Q8NB16

• Long Name
• Mixed Lineage Kinase Domain Like Pseudokinase

• Cellular Localization
• Cytoplasm; Cell membrane; Golgi apparatus

• Protein Refseq
• XP_011521238.1; XP_005255891.1

• Function
• Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, 22265414, 22421439, 24316671).
  Does not have protein kinase activity (PubMed:22265413, 22265414, 22421439, 24316671).
  Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage.

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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