Rabbit Anti-MLLT10 Recombinant Antibody (clone R07-2G2)
CAT#: VS3-FY1641
This product can be verification in WB, IHC assay. It is a rabbit recombinant monoclonal antibody that exhibits specific binding to human MLLT10. The recommended antibody dilution ratio is: western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5736/68_F4_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5747/69_H4_1_selected.jpg
Normal Tissue
Figure 3 IHC staining of human testis
Immunohistochemical staining of human testis shows strong nuclear positivity in cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/72790/171138_A_5_6_selected.jpg
Normal Tissue
Figure 4 High expression in testis
Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Round or early spermatids Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5747/21104_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078403-MLLT10
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Specifications
- Immunogen
- Recombinant human AF10 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human MLLT10
- Species Reactivity
- Human
- Clone
- R07-2G2
- Applications
- Western Blot, Immunohistochemistry-Paraffin
- MW
- The calculated weight of the target protein is approximately 113 kDa, while the observed molecular weight stands at 140 kDa.
- Related Disease
- Leukemia, Acute Myeloid and Precursor T-Cell Acute Lymphoblastic Leukemia
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor; Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 10; ALL1-Fused Gene From Chromosome 10 Protein; AF10; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 10; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 10
- Gene ID
- 8028
- UniProt ID
- P55197
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Isopeptide bond, Phosphoprotein, Ubl conjugation
- Protein Refseq
- NP_001182555.1; NP_001182556.1; NP_001182557.1; NP_001182559.1; NP_001311225.1
- Function
- Probably involved in transcriptional regulation. in vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "MLLT10"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0532MZ | Recombinant Mouse Anti-Human MLLT10 Antibody | WB | Mouse antibody |
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