Mouse Anti-MYOG Recombinant Antibody (clone ABT-MYOG)
CAT#: VS3-CJ667
This product is a mouse antibody that recognizes human MYOG.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28336/1666_C1_31_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HSkMC, RH-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000122180-MYOG
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Specifications
- Immunogen
- Synthesized peptide derived from human Myogenin
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human MYOG
- Species Reactivity
- Human
- Clone
- ABT-MYOG
- Applications
- IHC-P
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Immunohistochemistry-Parraffin (1:100-1:500).
Target
- Alternative Names
- MYF4; myf-4; bHLHc3
- Gene ID
- 4656
- UniProt ID
- P15173
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles (By similarity).
- Protein Refseq
- NP_002470.2
- Function
- Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "MYOG"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3215z | Mouse Anti-MYOG Recombinant Antibody (clone 29G7) | WB, ICC, IF, IHC | Mouse IgG1 |
| MOB-0133F | Mouse Anti-MYOG Recombinant Antibody (MOB-0133F) | IHC-P, IF | Mouse IgG |
| MOB-0134F | Mouse Anti-MYOG Recombinant Antibody (MOB-0134F) | IHC-P, IF | Mouse IgG |
| VS3-FY998 | Recombinant Mouse Anti-MYOG Antibody (clone 3G9-3A9-2B3) | IHC-P | Mouse IgG1 |
| VS3-XY3443 | Rabbit Anti-MYOG Recombinant Antibody (clone R01-7K6) | WB, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2353 | Hi-Affi™ Recombinant Rabbit Anti-MYOG Monoclonal Antibody (DS2353AB) | WB, IHC, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY197 | AbPlus™ Anti-MYOG Magnetic Beads (F12B) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4660 | Anti-MYOG Immunohistochemistry Kit | IHC | |
| VS-0525-XY4661 | Anti-Mouse MYOG Immunohistochemistry Kit | IHC | |
| VS-0525-XY4662 | Anti-Rat MYOG Immunohistochemistry Kit | IHC |
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