Mouse Anti-NEDD4 Recombinant Antibody (NE468)
CAT#: VS-0326-YC468
The anti-NEDD4 recombinant antibody (NE468) reacts with human NEDD4. NEDD4 is the prototypical HECT-domain E3 ligase that regulates the endocytosis and degradation of various ion channels and receptors, most notably the epithelial sodium channel (ENaC). NEDD4 signaling is a key regulator of salt balance and blood pressure. It also plays a significant role in TGF-beta and IGF-1 receptor signaling pathways. The anti-NEDD4 antibody (NE468) has been tested in Immunoprecipitation (IP).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/72833/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows cytoplasmic positivity in exocrine glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1991/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39883/90789_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39883/90789_A_7_3.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39883/90789_A_5_6.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000069869-NEDD4
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human NEDD4
- Species Reactivity
- Human
- Clone
- NE468
- Applications
- IP
- Conjugate
- The unconjugated, Biotin and FITC formats are available.
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- IP (1/100-1/200)
Target
- Alternative Names
- Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase; Cell Proliferation-Inducing Gene 53 Protein; HECT-Type E3 Ubiquitin Transferase NEDD4; Receptor-Potentiating Factor 1; NEDD4-1; Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4; Neural Precursor Cell Expressed, Developmentally Down-Regulated 4;
- Gene ID
- 4734
- UniProt ID
- P46934
- Long Name
- Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase
- Post Translation Modifications
- Unmodified
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "NEDD4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2814z | Mouse Anti-NEDD4 Recombinant Antibody (clone 1F9) | WB, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY1021 | Recombinant Rabbit Anti-NEDD4 Antibody (clone R06-7C3) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0426-FY607 | AibGenesis™ Rabbit Anti-NEDD4 Recombinant Antibody (AibG-Rb-NE607) | WB, FC, IP | Rabbit IgG |
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