Mouse Anti-NLRP12 Recombinant Antibody (VS3-FY2821) (CAT#: VS3-FY2821)
This anti-NLRP12 product is a recombinant mouse monoclonal antibody that has a high affinity for human NLRP12 protein. It cross-reacts with mouse species. The calculated molecular weight of the protein is about 120).1 kDa. This monoclonal antibody is suitable for employment in Western Blot (1/500-1/1000).
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows cytoplasmic positivity in hematopoietic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_B_5_4_selected.jpg
(Immunohistochemical staining of human bone marrow shows cytoplasmic positivity in hematopoietic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_B_5_4_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_B_8_5.jpg
(Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_B_8_5.jpg
Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_A_8_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_A_8_3.jpg
Figure 4 Liver
(Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_A_9_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_A_9_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_A_9_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_A_9_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_A_6_6.jpg
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_A_6_6.jpg
Figure 7 RNA cell line category: Group enriched (HMC-1, THP-1, U-87 MG, U-937)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000142405-NLRP12
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000142405-NLRP12
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human and Mouse NLRP12
- Species Reactivity
- Human, Mouse
- Applications
- Western Blot
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 120.1 kDa.
- Related Disease
- Familial Cold Autoinflammatory Syndrome 2 and Familial Cold Autoinflammatory Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- NLR Family Pyrin Domain Containing 12; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 12; PYRIN-Containing APAF1-Like Protein 7; Regulated By Nitric Oxide; PYPAF7; NALP12; RNO; NACHT, Leucine Rich Repeat And PYD Containing 12
- Gene ID
- 91662
- UniProt ID
- P59046
- Sequence Similarities
- Belongs to the NLRP family.
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (P59046)
Modification sites at neXtProt (NX_P59046)
Glycosylation from GlyGen (P59046) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011525782.1; XP_011525784.1; XP_016882951.1; XP_016882952.1
- Function
- Plays an essential role as an potent mitigator of inflammation (PubMed:30559449).
Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, 17947705).
Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449).
In turn, promotes bacterial tolerance.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2807z | Mouse Anti-NLRP12 Recombinant Antibody (clone 21D3) | WB, ELISA, IF, IP | Mouse IgG1, κ |
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