Mouse Anti-NLRP12 Recombinant Antibody (VS3-FY2821)
CAT#: VS3-FY2821
This anti-NLRP12 product is a recombinant mouse monoclonal antibody that has a high affinity for human NLRP12 protein. It cross-reacts with mouse species. The calculated molecular weight of the protein is about 120).1 kDa. This monoclonal antibody is suitable for employment in Western Blot (1/500-1/1000).
Gene Expression
Normal Tissue
Figure 1 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows cytoplasmic positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_B_5_4_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42981/97793_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (HMC-1, THP-1, U-87 MG, U-937)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000142405-NLRP12
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human and Mouse NLRP12
- Species Reactivity
- Human, Mouse
- Applications
- Western Blot
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 120.1 kDa.
- Related Disease
- Familial Cold Autoinflammatory Syndrome 2 and Familial Cold Autoinflammatory Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- NLR Family Pyrin Domain Containing 12; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 12; PYRIN-Containing APAF1-Like Protein 7; Regulated By Nitric Oxide; PYPAF7; NALP12; RNO; NACHT, Leucine Rich Repeat And PYD Containing 12
- Gene ID
- 91662
- UniProt ID
- P59046
- Sequence Similarities
- Belongs to the NLRP family.
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (P59046)
Modification sites at neXtProt (NX_P59046)
Glycosylation from GlyGen (P59046) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011525782.1; XP_011525784.1; XP_016882951.1; XP_016882952.1
- Function
- Plays an essential role as an potent mitigator of inflammation (PubMed:30559449).
Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, 17947705).
Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449).
In turn, promotes bacterial tolerance.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "NLRP12"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2807z | Mouse Anti-NLRP12 Recombinant Antibody (clone 21D3) | WB, ELISA, IF, IP | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2452 | Hi-Affi™ Recombinant Rabbit Anti-NLRP12 Monoclonal Antibody (DS2452AB) | IHC-Fr, IHC-P, IP, WB | IgG |
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