Anti-NME1 (clone W24V68) Recombinant Antibody Coupled Liposome (VS-1024-FY69)
CAT#: VS-1024-FY69
The application of anti-NME1 antibodies coupled with liposomes in breast cancer treatment is still under research. NME1 (NME/NM23 nucleoside diphosphate kinase 1) has been found to be associated with tumor progression in breast cancer cells, thus potential therapeutic strategies targeting its rapid pathological development are being developed. Liposomes, as a drug delivery system, can enhance the targeting and bioavailability of drugs, which may help improve treatment outcomes for breast cancer patients.
Liposomes conjugated with anti-NME1 antibodies have been developed for the treatment of melanoma, as NME1 is an important gene associated with tumor metastasis. The use of liposomes aims to increase drug concentration and efficacy at the tumor site. By targeting NME1, researchers hope to enhance the exposure of tumor cells to the drug and its apoptotic capability. Preliminary results suggest that this approach effectively inhibits tumor growth.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8467/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40571/if_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40571/84790_A_7_8.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40571/84790_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40571/84790_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Moderate Quantity: <25% Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40571/84790_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000239672-NME1
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More Infomation
Specifications
- Potential Clinical Applications
- Breast cancer, Melanoma
Product Composition
- Clone
- W24V68
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The recombinant mouse antibody exhibits a precise binding affinity for the human NME1 protein. This unique specificity is crucial for various applications in research and therapeutic contexts.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- NME1
- Introduction
- This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
- Alternative Names
- NME/NM23 Nucleoside Diphosphate Kinase 1; Non-Metastatic Cells 1, Protein (NM23A) Expressed In; Tumor Metastatic Process-Associated Protein; Metastasis Inhibition Factor Nm23; Granzyme A-Activated DNase; NDP Kinase A; EC 2.7.4.6; NM23-H1; NDPKA; GAAD
- Full Name
- NME/NM23 Nucleoside Diphosphate Kinase 1
- Gene ID
- 4830
- UniProt ID
- P15531
- Sequence Similarities
- Belongs to the NDK family.
- Cellular Localization
- Cytoplasm, Nucleus
- Positive Control
- The positive control samples for this antibody include Hela, A549, MCF-7, 293T lysates.
- Post Translation Modifications
- Ubiquitination at Lys100 (NX_P15531 [NX_P15531-1])
Modification sites at PhosphoSitePlus (P15531)
Glycosylation from GlyGen (P15531) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_000260.1; NP_937818.1
- Function
- Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2816z | Mouse Anti-NME1 Recombinant Antibody (clone 33H11) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG |
| MRO-2077-CN | Rabbit Anti-NME1 Polyclonal Antibody (MRO-2077-CN) | IF, IHC, FC, WB | Rabbit IgG |
| MRO-2078-CN | Rabbit Anti-NME1 Polyclonal Antibody (MRO-2078-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS-0923-FY120 | Recombinant Mouse Anti-NME1 Antibody (VS-0923-FY120) | ELISA, WB | Mouse IgG2b |
| VS13-YC818 | Rabbit Anti-NME1 Recombinant Antibody (VS13-YC818) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0394MZ | Chicken Anti-NME1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2456 | Hi-Affi™ Recombinant Rabbit Anti-NME1 Monoclonal Antibody (DS2456AB) | ICC, IF, IHC-P, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC686 | AbPlus™ Anti-NME1 Magnetic Beads (VS-0724-YC686) | IP, Protein Purification | |
| VS-0724-YC899 | AbPlus™ Anti-NME1 Magnetic Beads (VS-0724-YC899) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1500 | Anti-NME1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4874 | Anti-Mouse NME1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4873 | Anti-Human NME1 Immunohistochemistry Kit | IHC |
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