Anti-NME1 (clone W24V68) Recombinant Antibody Coupled Liposome (VS-1024-FY69) (CAT#: VS-1024-FY69)

• Potential Clinical Applications
• Breast cancer, Melanoma

• Clone
• W24V68

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• The recombinant mouse antibody exhibits a precise binding affinity for the human NME1 protein. This unique specificity is crucial for various applications in research and therapeutic contexts.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• NME1

• Introduction
• This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

• Alternative Names
• NME/NM23 Nucleoside Diphosphate Kinase 1; Non-Metastatic Cells 1, Protein (NM23A) Expressed In; Tumor Metastatic Process-Associated Protein; Metastasis Inhibition Factor Nm23; Granzyme A-Activated DNase; NDP Kinase A; EC 2.7.4.6; NM23-H1; NDPKA; GAAD

• Full Name
• NME/NM23 Nucleoside Diphosphate Kinase 1

• Gene ID
• 4830

• UniProt ID
• P15531

• Sequence Similarities
• Belongs to the NDK family.

• Cellular Localization
• Cytoplasm, Nucleus

• Positive Control
• The positive control samples for this antibody include Hela, A549, MCF-7, 293T lysates.

• Post Translation Modifications
• Ubiquitination at Lys100 (NX_P15531 [NX_P15531-1])
  Modification sites at PhosphoSitePlus (P15531)
  Glycosylation from GlyGen (P15531) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_000260.1; NP_937818.1

• Function
• Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities.

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