AbPlus™ Anti-NOG Magnetic Beads (VS-0724-YC400)
CAT#: VS-0724-YC400
The AbPlus Anti-NOG Magnetic Beads (VS-0724-YC400) is an innovative affinity resin which is bound with anti-NOG specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of NOG protein under native and denaturing conditions.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in decidual cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61318/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61318/141504_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61318/141504_A_8_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61318/141504_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61318/141504_A_6_6.jpg
Normal Tissue
Figure 6 Placenta
Decidual cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61318/141504_A_3_7.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61318/141504_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (EFO-21, LHCN-M2, NB-4, PC-3, U-2 OS)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000183691-NOG
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-NOG specific antibody
- Target
- NOG
- Immunogen
- A synthetic peptide corresponding to the N-terminus of the human NOG.
- Target Species
- Human, Mouse
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]
- Alternative Names
- Noggin; Symphalangism 1 (Proximal); Synostoses (Multiple) Syndrome 1; SYNS1A; SYNS1; SYM1;
- Gene ID
- 9241
- UniProt ID
- Q13253
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "NOG"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2645z | Mouse Anti-NOG Recombinant Antibody (clone 6G12) | WB, IF, IHC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2463 | Hi-Affi™ Recombinant Rabbit Anti-NOG Monoclonal Antibody (DS2463AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2080-CN | Rabbit Anti-NOG Polyclonal Antibody (MRO-2080-CN) | WB, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2081-CN | Rabbit Anti-NOG Polyclonal Antibody (MRO-2081-CN) | WB, IF, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0316C | Mouse Anti-NOG Recombinant Antibody (ZG-0316C) | WB, ICC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX825 | Mouse Anti-NOG Recombinant Antibody (clone 1D2-G8-G1) | WB, ICC | Mouse IgG3 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4890 | Anti-NOG Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4891 | Anti-Mouse NOG Immunohistochemistry Kit | IHC |
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