AbPlus™ Anti-NR3C1 Magnetic Beads (VS-0724-YC345) (CAT#: VS-0724-YC345)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magnetic bead

• Bead Ligand
• Anti-NR3C1 specific antibody

• Target
• NR3C1

• Immunogen
• Synthetic peptide corresponding to the center region of the human NR3C1.

• Target Species
• Human

• Bead Capacity
• 40 mg/mL

• Bead size
• 25 μm

• Format
• Suspension

• Concentration
• 2 mg/mL

• Buffer
• PBS, pH 7.4

• Preservative
• 0.1% Sodium azide

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

• Alternative Names
• Nuclear Receptor Subfamily 3 Group C Member 1; Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor); Glucocorticoid Receptor; GRL; GR; Nuclear Receptor Subfamily 3, Group C, Member 1;

• Gene ID
• 2908

• UniProt ID
• P04150

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