CytoStream™ Mouse Anti-NR3C1 Recombinant Antibody (VS13-YC840)
CAT#: VS13-YC840
The CytoStream™ Mouse Anti-NR3C1 Recombinant Antibody is specific for human and mouse NR3C1. NR3C1 encodes the glucocorticoid receptor, a transcription factor regulating inflammatory responses and proliferation, with mutations causing glucocorticoid resistance. Alternative splicing and translation produce functional variants. The anti-NR3C1 antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4248/78_E8_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, cytosol & mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10435/if_selected.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Peritubular cells Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10435/26792_A_6_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10435/26792_A_7_8.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10435/26792_A_8_4.jpg
Normal Tissue
Figure 6 Pancreas
Exocrine glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10435/26792_A_3_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10435/26792_A_9_5.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113580-NR3C1
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Specifications
- Immunogen
- Recombinant full-length human glucocorticoid receptor alpha.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human and Mouse NR3C1
- Species Reactivity
- Human, Mouse
- Applications
- WB, IHC-P, FC, ICC, IF
- Conjugate
- NONE
- Related Disease
- Glucocorticoid Resistance, Generalized and Conn's Syndrome
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4) containing 50% Glycerol and 0.2% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000-1/2000
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Immunocytochemistry (ICC): 1/50
Target
- Alternative Names
- Nuclear Receptor Subfamily 3 Group C Member 1; Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor); Glucocorticoid Receptor; GRL; GR; Nuclear Receptor Subfamily 3, Group C, Member 1;
- Gene ID
- 2908
- UniProt ID
- P04150
- Long Name
- Nuclear Receptor Subfamily 3 Group C Member 1
- Sequence Similarities
- Belongs to the nuclear hormone receptor family. NR3 subfamily.
- Cellular Localization
- Nucleus; Cytoplasm
- Protein Refseq
- NP_000167.1; NP_001018084.1; NP_001018085.1; NP_001018086.1; NP_001018087.1
- Function
- Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "NR3C1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1788CQ | Recombinant Mouse Anti-NR3C1 Antibody (BuGR2) | WB, Neut, ChIP, FC, GS, ICC, IF, IHC, IHC-P, IP | IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2493 | Hi-Affi™ Recombinant Rabbit Anti-NR3C1 Monoclonal Antibody (DS2493AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0664-CN | Recombinant Rabbit Anti-NR3C1 Monoclonal Antibody (JF0952) | WB, FC | Rabbit IgG |
| MRO-0665-CN | Recombinant Mouse Anti-NR3C1 Monoclonal Antibody (3F1) | WB, IF, IHC, FC | Mouse IgG2a |
| VS3-FY1067 | Recombinant Rabbit Anti-Nr3C1 Antibody (clone R04-8C8) | WB, ICC, IF | Rabbit IgG |
| VS3-FY1960 | Rabbit Anti-NR3C1 Recombinant Antibody (clone R02-5A3) | WB | Rabbit IgG |
| VS3-WK2028 | Rabbit Anti-NR3C1 (pS226) Recombinant Antibody (clone R02-1H0) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC345 | AbPlus™ Anti-NR3C1 Magnetic Beads (VS-0724-YC345) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1514 | Anti-NR3C1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4960 | Anti-Mouse NR3C1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4959 | Anti-Human NR3C1 Immunohistochemistry Kit | IHC |
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