Anti-OLIG2 (clone W24V118) Recombinant Antibody Coupled Liposome (VS-1024-FY120) (CAT#: VS-1024-FY120)

• Potential Clinical Applications
• Glioma

• Clone
• W24V118

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody that has been engineered to specifically target and bind to human OLIG2 protein. OLIG2 is an important transcription factor involved in the development and differentiation of oligodendrocytes, playing a crucial role in the central nervous system. By utilizing this antibody in research, scientists can gain insights into neurological diseases and the mechanisms of oligodendrocyte function and pathology.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• OLIG2

• Introduction
• This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.

• Alternative Names
• Oligodendrocyte Transcription Factor 2; Oligodendrocyte-Specific BHLH Transcription Factor 2; Basic Domain; Helix-Loop-Helix Protein; Class B; 1; Oligodendrocyte Lineage Transcription Factor 2; Human Protein Kinase C-Binding Protein RACK17; Class E Basic Helix-Loop-Helix Protein 19; Class B Basic Helix-Loop-Helix Protein 1; Protein Kinase C Binding Protein 2

• Full Name
• Oligodendrocyte Transcription Factor 2

• Gene ID
• 10215

• UniProt ID
• Q13516

• Cellular Localization
• Nucleus; Cytoplasm

• Post Translation Modifications
• Modification sites at PhosphoSitePlus ( Q13516 )
  Modification sites at neXtProt ( NX_Q13516 )
  Glycosylation from GlyGen (Q13516) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_005260965.1; XP_054180275.1; NP_005797.1

• Function
• Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain.
  Functions together with ZNF488 to promote oligodendrocyte differentiation.
  Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube.

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