Anti-OLIG2 (clone W24V118) Recombinant Antibody Coupled Liposome (VS-1024-FY120)
CAT#: VS-1024-FY120
OLIG2 antibody-conjugated liposomes have shown potential in the study of gliomas. The OLIG2 antibody is capable of recognizing normal oligodendrocytes and is used for the diagnosis of certain brain tumors. In further research, a liposome system modified with transferrin was utilized to achieve receptor-mediated transport, allowing for more effective targeting of glioma cells by the antibody.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3254/if_selected.jpg
Normal Tissue
Figure 2 High expression in cerebral cortex
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19381/42827_B_9_5.jpg
Normal Tissue
Figure 3 Caudate
Glial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19381/42827_B_7_7.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19381/42827_A_4_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HMC-1, NB-4, THP-1, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000205927-OLIG2
❮
❯
More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V118
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that has been engineered to specifically target and bind to human OLIG2 protein. OLIG2 is an important transcription factor involved in the development and differentiation of oligodendrocytes, playing a crucial role in the central nervous system. By utilizing this antibody in research, scientists can gain insights into neurological diseases and the mechanisms of oligodendrocyte function and pathology.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- OLIG2
- Introduction
- This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
- Alternative Names
- Oligodendrocyte Transcription Factor 2; Oligodendrocyte-Specific BHLH Transcription Factor 2; Basic Domain; Helix-Loop-Helix Protein; Class B; 1; Oligodendrocyte Lineage Transcription Factor 2; Human Protein Kinase C-Binding Protein RACK17; Class E Basic Helix-Loop-Helix Protein 19; Class B Basic Helix-Loop-Helix Protein 1; Protein Kinase C Binding Protein 2
- Full Name
- Oligodendrocyte Transcription Factor 2
- Gene ID
- 10215
- UniProt ID
- Q13516
- Cellular Localization
- Nucleus; Cytoplasm
- Post Translation Modifications
- Modification sites at PhosphoSitePlus ( Q13516 )
Modification sites at neXtProt ( NX_Q13516 )
Glycosylation from GlyGen (Q13516) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_005260965.1; XP_054180275.1; NP_005797.1
- Function
- Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain.
Functions together with ZNF488 to promote oligodendrocyte differentiation.
Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1024-FY120. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "OLIG2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2173z | Mouse Anti-OLIG2 Recombinant Antibody (clone 4C1) | WB, ELISA, IF, IHC | Mouse IgG2a |
| MOB-2222MZ | Recombinant Mouse Anti-Human OLIG2 Antibody (clone 2H22) | ELISA, ICC, IF, IHC-P, WB | Mouse antibody |
| VS3-QX842 | Mouse Anti-OLIG2 Recombinant Antibody (clone 7A1-B12-G4) | WB | Mouse IgG1 |
| VS3-WK938 | Rabbit Anti-OLIG2 Recombinant Antibody (VS3-WK938) | WB, IHC | Rabbit IgG |
| VS7-0425-WR522 | Mouse Anti-OLIG2 Monoclonal Antibody (VS7-0425-WR522) | WB, IHC-P, IF, ICC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2542 | Hi-Affi™ Recombinant Rabbit Anti-OLIG2 Monoclonal Antibody (DS2542AB) | IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1542 | Anti-OLIG2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5086 | Anti-Human OLIG2 Immunohistochemistry Kit | IHC |
See Our Custom Production in Action
Popular Products
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: ELISA
-2-1.png)
Application: ELISA
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: WB, FC, IF, Inhib, ELISA, IHC
Application: WB, IHC-Fr, IHC-P, ICC, IF
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
