AbPlus™ Anti-PAX5 Magnetic Beads (VS-0724-YC172)
CAT#: VS-0724-YC172
The AbPlus Anti-PAX5 Magnetic Beads (VS-0724-YC172) is an innovative affinity resin which is bound with anti-PAX5 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of PAX5 protein under native and denaturing conditions.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56394/2055_D7_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68498/1354_G10_4_selected.jpg
Normal Tissue
Figure 3 IHC staining of human lymph node
High expression. RNA expression: 39.7 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56394/140587_A_8_8_val_selected.jpg
Normal Tissue
Figure 4 IHC staining of human cerebral cortex
Low expression. RNA expression: 0.5 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56394/140587_B_8_5_val_selected.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56394/140587_A_7_5.jpg
Normal Tissue
Figure 6 Spleen
Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
Cells in white pulp
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56394/140587_B_9_4.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (Daudi, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196092-PAX5
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-PAX5 specific antibody
- Target
- PAX5
- Immunogen
- Synthetic peptide corresponding to the N-terminus of the human PAX5.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
- Alternative Names
- Paired Box 5; B-Cell Lineage Specific Activator; BSAP; Paired Box Gene 5 (B-Cell Lineage Specific Activator Protein); Paired Box Gene 5 (B-Cell Lineage Specific Activator); B-Cell-Specific Transcription Factor;
- Gene ID
- 5079
- UniProt ID
- Q02548
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "PAX5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-752-F(E) | Recombinant Anti-human PAX5 Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| MHH-752-F(E) | Recombinant Human Anti-human PAX5 Antibody Fab Fragment | ELISA, WB, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-752-S(P) | Recombinant Anti-human PAX5 Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| MHH-752-S(P) | Recombinant Human Anti-human PAX5 Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2114MZ | Recombinant Mouse Anti-Human PAX5 Antibody (clone nBcdbn63699) | WB | Mouse antibody |
| MRO-1170-CN | Recombinant Rabbit Anti-PAX5 Monoclonal Antibody (CBACN-427) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-0669F | Rabbit Anti-PAX5 Recombinant Antibody (ZG-0669F) | IHC-Fr, IHC-P | Rabbit IgG |
| VS3-XY1212 | Mouse Anti-PAX5 Recombinant Antibody (clone 7D3) | ELISA, WB, IHC | Mouse IgG1 |
| VS3-XY1213 | Mouse Anti-PAX5 Recombinant Antibody (clone 4G6) | WB, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2601 | Hi-Affi™ Recombinant Rabbit Anti-PAX5 Monoclonal Antibody (DS2601AB) | ICC, WB | IgG |
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