Anti-PAX8 Antibody Prodrug, Protease Activated (VS-1025-YC131)
CAT#: VS-1025-YC131
The Anti-PAX8 Antibody Prodrug, Protease Activated (VS-1025-YC131) is an antibody prodrug comprised of a recombinant mouse antibody targeting human PAX8, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to PAX8 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to PAX8 effectively. PAX8 is a transcription factor whose expression is characteristic of thyroid and ovarian cancers. Its utility in oncology is primarily as a diagnostic marker used to confirm the tissue origin of a tumor of unknown primary (CUP) or metastatic lesions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30062/297_D7_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line RPTEC TERT1
Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64554/1789_E6_5_cr598aeb34d7793_selected.jpg
Normal Tissue
Figure 3 Kidney
Bowman's capsule Staining: High Intensity: Strong Quantity:>75% Collecting ducts Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61888/136405_A_7_5.jpg
Normal Tissue
Figure 4 Thyroid gland
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61888/136405_B_3_5.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61888/136405_A_8_4.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (EFO-21, GAMG, RPTEC TERT1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000125618-PAX8
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human PAX8
- Target
- PAX8
- Species Reactivity
- Human
- Isotype
- IgG1, kappa
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein G purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
- Alternative Names
- PAX8; paired box 8
- Gene ID
- 7849
- UniProt ID
- Q06710
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "PAX8"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2098z | Mouse Anti-PAX8 Recombinant Antibody (clone 34A10) | WB, FC, IF, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0940CL | Mouse Anti-PAX8 Recombinant Antibody (TAB-0940CL) | WB, IHC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0940CL-S(P) | Mouse Anti-PAX8 Recombinant Antibody; scFv Fragment (TAB-0940CL-S(P)) | ELISA, WB, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0940CL-F(E) | Mouse Anti-PAX8 Recombinant Antibody; Fab Fragment (TAB-0940CL-F(E)) | ELISA, WB, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1557CT | Recombinant Mouse anti-Human PAX8 Monoclonal antibody (2D6) | ELISA, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2604 | Hi-Affi™ Recombinant Rabbit Anti-PAX8 Monoclonal Antibody (DS2604AB) | IHC-P, IHC-Fr | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1174-CN | Recombinant Mouse Anti-PAX8 Monoclonal Antibody (6G5) | WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1175-CN | Recombinant Rabbit Anti-PAX8 Monoclonal Antibody (CBACN-431) | IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1176-CN | Recombinant Rabbit Anti-PAX8 Monoclonal Antibody (CBACN-432) | WB, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC152 | AbPlus™ Anti-PAX8 Magnetic Beads (VS-0724-YC152) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY368 | Mouse Anti-NHP PAX8 Recombinant Antibody (clone 1F8-3A8) | WB, IHC, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1571 | Anti-PAX8 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5212 | Anti-Mouse PAX8 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5213 | Anti-Human PAX8 Immunohistochemistry Kit | IHC |
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