SmartAb™ Recombinant Anti-PDGFC pH-dependent Antibody (VS-0825-YC281)
CAT#: VS-0825-YC281
The anti-PDGFC pH-dependent antibody (VS-0825-YC281) targets human PDGFC in a pH-dependent manner, with its affinity remaining high at neutral pH but weakening at a lower pH, such as within the acidic environment of endosomes. The anti-PDGFC acid-switched antibody was engineered by incorporating histidine residues into its variable regions. The introduction of histidine substitutions within its Complementarity-Determining Regions (CDRs) enables pH-responsive antigen binding, which leads to enhanced PDGFC clearance. The antibody operates in a cyclical manner, binding PDGFC in the extracellular fluid and releasing it in acidified endosomes. Human PDGFC (Platelet-Derived Growth Factor C) is a growth factor that, upon proteolytic cleavage, activates the PDGF-Rα receptor. It is involved in embryonic development and has been implicated in the development and progression of cancer.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9134/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows distinct positivity in plasma.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9134/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9134/69719_B_8_5.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9134/69719_A_9_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9134/69719_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (fHDF/TERT166, hTERT-RPE1, U-138 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145431-PDGFC
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1 kappa
- Specificity
- Human PDGFC
- Species Reactivity
- Human
- Applications
- ELISA, Inhib
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "PDGFC"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-758 | Recombinant Anti-human PDGFC Antibody | WB, Dot, FuncS | IgG |
| MHH-758 | Recombinant Human Anti-human PDGFC Antibody | IP, IF, Biosensors, FuncS | IgG |
| HPAB-0013-LS | Mouse Anti-PDGFC Recombinant Antibody (HPAB-0013-LS) | ELISA, Inhib | Mouse IgG1 κ |
| HPAB-0014-LS | Mouse Anti-PDGFC Recombinant Antibody (HPAB-0014-LS) | ELISA, Inhib | Mouse IgG2b κ |
| HPAB-0015-LS | Mouse Anti-PDGFC Recombinant Antibody (HPAB-0015-LS) | ELISA, Inhib | Mouse IgG1 κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-758-F(E) | Recombinant Anti-human PDGFC Antibody Fab Fragment | ELISA, FacS, FuncS | Fab |
| HPAB-0014-LS-S(P) | Mouse Anti-PDGFC Recombinant Antibody; scFv Fragment (HPAB-0014-LS-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-0015-LS-S(P) | Mouse Anti-PDGFC Recombinant Antibody; scFv Fragment (HPAB-0015-LS-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-0016-LS-S(P) | Human Anti-PDGFC Recombinant Antibody; scFv Fragment (HPAB-0016-LS-S(P)) | ELISA, Inhib | Humanized scFv |
| HPAB-0017-LS-S(P) | Mouse Anti-PDGFC Recombinant Antibody; scFv Fragment (HPAB-0017-LS-S(P)) | ELISA, Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-758-S(P) | Recombinant Anti-human PDGFC Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| MHH-758-S(P) | Recombinant Human Anti-human PDGFC Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| HPAB-0013-LS-F(E) | Mouse Anti-PDGFC Recombinant Antibody; Fab Fragment (HPAB-0013-LS-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-0014-LS-F(E) | Mouse Anti-PDGFC Recombinant Antibody; Fab Fragment (HPAB-0014-LS-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-0015-LS-F(E) | Mouse Anti-PDGFC Recombinant Antibody; Fab Fragment (HPAB-0015-LS-F(E)) | ELISA, Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0982CL-S(P) | Mouse Anti-PDGFC Recombinant Antibody; scFv Fragment (TAB-0982CL-S(P)) | ELISA | Mouse scFv |
| TAB-0983CL-S(P) | Mouse Anti-PDGFC Recombinant Antibody; scFv Fragment (TAB-0983CL-S(P)) | ELISA | Mouse scFv |
| TAB-0984CL-S(P) | Mouse Anti-PDGFC Recombinant Antibody; scFv Fragment (TAB-0984CL-S(P)) | ELISA | Mouse scFv |
| TAB-0985CL-S(P) | Mouse Anti-PDGFC Recombinant Antibody; scFv Fragment (TAB-0985CL-S(P)) | ELISA | Mouse scFv |
| TAB-0986CL-S(P) | Mouse Anti-PDGFC Recombinant Antibody; scFv Fragment (TAB-0986CL-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1843CQ | Recombinant Mouse Anti-PDGFC Antibody (5F12) | WB, Neut | IgG2 |
| NEUT-1844CQ | Recombinant Mouse Anti-PDGFC Antibody (CBL152) | Neut | IgG2 |
| NEUT-1845CQ | Recombinant Mouse Anti-PDGFC Antibody (CBL634) | Neut | IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC250 | Recombinant Anti-PDGFC Eliminating Antibody, pH-Sensitive (VS-0625-YC250) | Antigen-Sweeping In Vivo. | Mouse IgG1 kappa |
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