Rabbit Anti-PER3 Recombinant Antibody (clone R74-4J-9) (CAT#: VS3-FY2132)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat PER3

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R74-4J-9

• Applications
• Western Blot

• Conjugate
• Unconjugated

• MW
• The calculated weight of the target protein is approximately 132kDa, while the observed molecular weight stands at 132kDa.

• Related Disease
• Advanced Sleep Phase Syndrome, Familial, 3 and Advanced Sleep Phase Syndrome

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS (pH 7.4), 150 mM NaCl, 50% glycerol

• Preservative
• 0.02% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• Period Circadian Regulator 3; Cell Growth-Inhibiting Gene 13 Protein; Circadian Clock Protein PERIOD 3; Period Circadian Clock 3; HPER3; Period Circadian Protein Homolog 3

• Gene ID
• 8863

• UniProt ID
• P56645

• Cellular Localization
• Cytoplasm, Nucleus

• Post Translation Modifications
• Phosphorylation by CSNK1E is weak and appears to require association with PER1 and translocation to the nucleus. (P56645-PER3_HUMAN)
  Ubiquitinated. (P56645-PER3_HUMAN)
  Modification sites at PhosphoSitePlus (P56645)
  Modification sites at neXtProt (NX_P56645)
  Glycosylation from GlyGen (P56645) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_005263581.1; XP_016858212.1; XP_016858213.1; XP_016858215.1; XP_016858218.2

• Function
• It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody