Rabbit Anti-PLSCR3 Recombinant Antibody (clone R02-1B9)
CAT#: VS3-FY1837
Clone R02-1B9 is a rabbit recombinant monoclonal antibody that is specific for human PLSCR3. It cross-reacts with mouse, rat. The PLSCR3 antibody is recommended for detection of target protein by western blot analysis of PLSCR3 in rat lung, mouse lung lysates.
Gene Expression
Tested Data
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48387/1717_B11_13_cr58060a212c81f_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68609/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68609/149764_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Fibroblasts
Staining: Medium
Intensity: Moderate
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68609/149764_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68609/149764_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68609/149764_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Spermatogonia cells
Staining: Low
Intensity: Moderate
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68609/149764_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68609/149764_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000187838-PLSCR3/subcellular
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❯
WB
Figure 1 Anti-PLSCR3 Antibody (VS3-FY1837) in WB.
The PLSCR3 expression in rat lung, mouse lung lysates were detected using the anti-PLSCR3 by western blot assay.
❮
❯
Specifications
- Immunogen
- Synthetic peptides of human PLSCR3
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat PLSCR3
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R02-1B9
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 32 kDa, while the observed molecular weight stands at 32 kDa.
- Related Disease
- Barth Syndrome
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- phospholipid scramblase 3; PLSCR3
- Gene ID
- 57048
- UniProt ID
- Q9NRY6
- Sequence Similarities
- Belongs to the phospholipid scramblase family.
- Cellular Localization
- Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus
- Post Translation Modifications
- Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances phospholipid scramblase activity. (Q9NRY6-PLS3_HUMAN)
Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. (Q9NRY6-PLS3_HUMAN)
Modification sites at PhosphoSitePlus (Q9NRY6)
Modification sites at neXtProt
- Protein Refseq
- NP_001188505.1; NP_001356336.1; NP_001356349.1; NP_001356350.1; NP_001356351.1
- Function
- Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response.
Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "PLSCR3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1281CT | Recombinant Mouse anti-Human PLSCR3 Monoclonal antibody (EML1732) | WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2757 | Hi-Affi™ Recombinant Rabbit Anti-PLSCR3 Monoclonal Antibody (DS2757AB) | WB | IgG |
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