Rabbit Anti-PRDX6 Recombinant Antibody (clone R03-7F5) (CAT#: VS3-FY2062)

• Immunogen
• Synthetic peptide of human peroxiredoxin 6

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human PRDX6

• Species Reactivity
• Human

• Clone
• R03-7F5

• Applications
• Western Blot, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 25 kDa, while the observed molecular weight stands at 25 kDa.

• Related Disease
• Gnathomiasis and Down Syndrome

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunoprecipitation: 1/20

• Alternative Names
• PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; LPCAT-5; HEL-S-128m

• Gene ID
• 9588

• UniProt ID
• P30041

• Sequence Similarities
• Belongs to the peroxiredoxin family. Prx6 subfamily.

• Cellular Localization
• Cytoplasm, Lysosome

• Post Translation Modifications
• Irreversibly inactivated by overoxidation of Cys-47 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress. (P30041-PRDX6_HUMAN)
  Phosphorylation at Thr-177 by MAP kinases increases the phospholipase activity of the enzyme ().
  The phosphorylated form exhibits a greater lysophosphatidylcholine acyltransferase activity compared to the non-phosphorylated form (PubMed:26830860).
  (P30041-PRDX6_HUMAN)
  Ubiquitination at Lys209 (NX_P30041 [NX_P30041-1])
  Modification sites at PhosphoSitePlus (P30041)
  Glycosylation from GlyGen (P30041) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_004896.1

• Function
• Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis.
  Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC).

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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