Mouse Anti-RAB27A Recombinant Antibody (VS3-FY2853) (CAT#: VS3-FY2853)
The anti-RAB27A product is a mouse recombinant monoclonal antibody. It has been specifically designed to target the human, mouse, rat RAB27A protein, a calculated molecular weight of the protein is about 24.9 kDa. This monoclonal antibody proves valuable in disease research related to Griscelli Syndrome, Type 2 and Griscelli Syndrome. The antibody can be utilized for detection of RAB27A by Western Blot (1/500-1/1000) and Flow cytometry (1/10-1/25).
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Normal Tissue
RNA Expression
Figure 1 Stomach 1
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1333/4092_A_5_1_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1333/4092_A_5_1_val_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34046/86912_B_9_5.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34046/86912_B_9_5.jpg
Figure 3 Colon
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34046/85405_A_9_3.jpg
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34046/85405_A_9_3.jpg
Figure 4 RNA cell line category: Cell line enhanced (HL-60, K-562, Karpas-707, SK-MEL-30, U-937)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000069974-RAB27A
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000069974-RAB27A
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human, Mouse and Rat RAB27A
- Species Reactivity
- Human, Mouse, Rat
- Applications
- Western Blot, Flow cytometry
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 24.9 kDa.
- Related Disease
- Griscelli Syndrome, Type 2 and Griscelli Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Flow cytometry: 1/10-1/25
Target
- Alternative Names
- RAB27A, Member RAS Oncogene Family; GTP-Binding Protein Ram; Rab-27; RAB27; Mutant Ras-Related Protein Rab-27A; Ras-Related Protein Rab-27A; HsT18676; RAM; GS2
- Gene ID
- 5873
- UniProt ID
- P51159
- Sequence Similarities
- Belongs to the small GTPase superfamily. Rab family.
- Cellular Localization
- Endosome, Lysosome, Membrane
- Protein Refseq
- NP_004571.2; NP_899057.1; NP_899058.1
- Function
- Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381).
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1745CT | Recombinant Mouse anti-Human RAB27A Monoclonal antibody (EML672) | ICC/IF, IHC-FoFr, IHC-P, IP, WB | |
| VS3-QX944 | Mouse Anti-RAB27A Recombinant Antibody (clone 9D-7C) | WB, IHC | Mouse IgG2b |
| VS3-CJ1016 | Mouse Anti-RAB27A Recombinant Antibody (VS3-CJ1016) | WB, FC | Mouse IgG1, κ |
| VS3-XY1349 | Mouse Anti-RAB27A Recombinant Antibody (clone 7D7C9) | IHC | Mouse IgG2b |
| VS4-CJ100 | Recombinant Rabbit Anti-RAB27A Antibody (clone 2E8) | ELISA, FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
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