Rabbit Anti-RAB29 Recombinant Antibody (clone R08-3C0) (CAT#: VS3-FY2074)

• Immunogen
• Recombinant human RAB29 protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human RAB29

• Species Reactivity
• Human

• Clone
• R08-3C0

• Applications
• Western Blot, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 23 kDa, while the observed molecular weight stands at 23 kDa.

• Related Disease
• Parkinson Disease 21 and Kufor-Rakeb Syndrome

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunoprecipitation: 1/20

• Alternative Names
• RAB29, Member RAS Oncogene Family; RAB7, Member RAS Oncogene Family-Like 1; Ras-Related Protein Rab-29; Rab-7-Like Protein 1; RAB7L1; Ras-Related Protein Rab-7L1; RAB7L

• Gene ID
• 8934

• UniProt ID
• O14966

• Sequence Similarities
• Belongs to the small GTPase superfamily. Rab family.

• Cellular Localization
• Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Vacuole

• Post Translation Modifications
• In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles.
  In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells (PubMed:22042847).
  (O14966-RAB7L_HUMAN)
  Modification sites at PhosphoSitePlus (O14966)
  Modification sites at neXtProt (NX_O14966)

• Protein Refseq
• XP_005245626.1; XP_005245627.1; XP_005245628.1; XP_006711668.1; XP_006711669.1

• Function
• The small GTPases Rab are key regulators in vesicle trafficking.
  Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity).
  Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody