Rabbit Anti-RALB Recombinant Antibody (clone R08-6E3) (CAT#: VS3-FY1867)
The R08-6E3 recombinant antibody exhibits specific detecting to human RALB protein, a calculated weight of 23 kDa. It cross-reacts with mouse.
The following recommendations serve as a starting point for assay optimization. The actual working concentration may vary and should be determined by the user. The R08-6E3 is recommended for detection of target protein by western blotting (dilution range 1:500-1:1000), immunoprecipitation (dilution range 1:20).
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Normal Tissue
RNA Expression
Figure 1 High expression in parathyroid gland.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26010/164336_A_2_8_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26010/164336_A_2_8_selected.jpg
Figure 2 Low expression in liver.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26010/164336_A_8_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26010/164336_A_8_4_val_selected.jpg
Figure 3 Parathyroid gland
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26010/164336_A_2_8.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26010/164336_A_2_8.jpg
Figure 4 Kidney
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26010/164336_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26010/164336_A_8_5.jpg
Figure 5 Lymph node
(Non-germinal center cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26010/164336_A_9_8.jpg
(Non-germinal center cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26010/164336_A_9_8.jpg
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000144118-RALB
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000144118-RALB
Specifications
- Immunogen
- Synthetic peptide of human RALB
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse RALB
- Species Reactivity
- Human, Mouse
- Clone
- R08-6E3
- Applications
- Western Blot, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 23 kDa, while the observed molecular weight stands at 23 kDa.
- Related Disease
- Pancreatic Cancer and Bladder Cancer
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunoprecipitation: 1/20
Target
- Alternative Names
- RAS Like Proto-Oncogene B; V-Ral Simian Leukemia Viral Oncogene Homolog B; Ras Related GTP Binding Protein B
- Gene ID
- 5899
- UniProt ID
- P11234
- Sequence Similarities
- Belongs to the small GTPase superfamily. Ras family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Prenylation is essential for membrane localization.
The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).
- Protein Refseq
- XP_005263785.1; XP_047301313.1; XP_047301314.1; XP_047301315.1; XP_047301316.1
- Function
- Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking.
Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3415z | Mouse Anti-RALB Recombinant Antibody (clone 24F7) | WB, ELISA, FC, IHC | Mouse IgG2b |
| MOB-1767CT | Recombinant Mouse anti-Human RALB Monoclonal antibody (5E2) | IHC-P, IP, WB, sELISA | |
| VS7-0425-WR763 | Mouse Anti-RALB Recombinant Antibody (clone 8A8A9) | WB, FC | Mouse IgG2a |
| VS7-0425-WR764 | Mouse Anti-RALB Recombinant Antibody (clone 7F8B4) | WB, IHC, FC | Mouse IgG2b |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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