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  • Rabbit Anti-RASGRF1 Recombinant Antibody (clone R06-5H5)

Rabbit Anti-RASGRF1 Recombinant Antibody (clone R06-5H5) (CAT#: VS3-FY1680)

This product is a extraordinary rabbit recombinant monoclonal antibody that shows specific binding to human and rat RASGRF1. The calculated molecular weight of the antigen is 145 kDa; the observed molecular weight of the protein is 145 kDa. The R06-5H5 is recommended for dilution with western blot (dilution 1/500-1/1000).


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Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41965/if_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10413/if_selected.jpg
Normal Tissue
Figure 3 Lymph node
Figure 3 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41965/90759_A_9_8.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41965/90759_A_9_5.jpg
Figure 5 Testis
Figure 5 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41965/90759_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, BEWO, Karpas-707, RPMI-8226, U-2 OS)
Figure 6 RNA cell line category: Cell line enhanced (A-431, BEWO, Karpas-707, RPMI-8226, U-2 OS)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000058335-RASGRF1

Specifications

  • Immunogen
  • Synthetic peptide of human CDC25
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human and Rat RASGRF1
  • Species Reactivity
  • Human, Rat
  • Clone
  • R06-5H5
  • Applications
  • Western Blot
  • MW
  • The calculated weight of the target protein is approximately 145 kDa, while the observed molecular weight stands at 145 kDa.
  • Related Disease
  • Bleeding Disorder, Platelet-Type, 18 and Degenerative Myopia

Product Property

  • Purification
  • Affinity Purified
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Western Blot: 1/500-1/1000

Target

  • Alternative Names
  • Ras Protein Specific Guanine Nucleotide Releasing Factor 1; Ras-Specific Nucleotide Exchange Factor CDC25; Guanine Nucleotide-Releasing Protein; Ras-GRF1; CDC25; GRF1; GNRP; Ras-Specific Guanine Nucleotide-Releasing Factor, CDC25 Homolog; Ras-Specific Guanine Nucleotide-Releasing Factor 1
  • Cellular Localization
  • cytosol, growth cone, neuron projection, plasma membrane
  • Post Translation Modifications
  • Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome.
    Ubiquitinated and degraded following phosphorylation by PLK2.
    Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.
  • Function
  • Promotes the exchange of Ras-bound GDP by GTP.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "RASGRF1"

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3009 Hi-Affi™ Recombinant Rabbit Anti-RASGRF1 Monoclonal Antibody (DS3009AB) WB IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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