Mouse Anti-RBCK1 Recombinant Antibody (VS3-FY2862)
CAT#: VS3-FY2862
This anti-RBCK1 antibody is a mouse recombinant monoclonal antibody that is specifically created to target human RBCK1 protein. It cross-reacts with mouse, rat species. The calculated molecular weight of the protein is about 57.6 kDa. The monoclonal antibody can be used in the area of Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency and Glycogen Storage Disease Iv. The antibody can be utilized for detection of RBCK1 by Western Blot (1/500-1/2000).
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (hTCEpi)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125826-RBCK1
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human, Mouse and Rat RBCK1
- Species Reactivity
- Human, Mouse, Rat
- Applications
- Western Blot
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 57.6 kDa.
- Related Disease
- Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency and Glycogen Storage Disease Iv
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Target
- Alternative Names
- RANBP2-Type And C3HC4-Type Zinc Finger Containing 1; Heme-Oxidized IRP2 Ubiquitin Ligase 1; RING-Type E3 Ubiquitin Transferase HOIL-1; Hepatitis B Virus X-Associated Protein 4; HBV-Associated Factor 4; RING Finger Protein 54; C20orf18; UBCE7IP3; HOIL-1; RNF54; XAP3; XAP4; RanBP-Type And C3HC4-Type Zinc Finger-Containing Protein 1
- Gene ID
- 10616
- UniProt ID
- Q9BYM8
- Sequence Similarities
- Belongs to the RBR family.
- Cellular Localization
- cytosol, nucleus
- Post Translation Modifications
- Auto-ubiquitinated.
Auto-ubiquitination leads to degradation by the proteasome (By similarity).
(Q9BYM8-HOIL1_HUMAN)
Phosphorylated.
In vitro, phosphorylation inhibits auto-ubiquitination activity (By similarity).
(Q9BYM8-HOIL1_HUMAN)
(Microbial infection) Ubiquitinated by S.flexneri E3 ubiquitin-protein ligases IpaH1.4 and IpaH2.5, leading to its degradation by the proteasome, thereby preventing formation of the bacterial ubiquitin coat and activation of innate immunity (PubMed:27572974, 35294289). (Q9BYM8-HOIL1_HUMAN)
Ubiquitination at Lys29, Lys158, Lys174, Lys254, and Lys342 (NX_Q9BYM8 [NX_Q9BYM8-1])
Modification sites at PhosphoSitePlus
- Protein Refseq
- XP_011527440.1; XP_011527441.1; XP_011527442.1; XP_047295789.1
- Function
- Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548).
Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, 18711448).
Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, 21455173, 21455180, 21455181, 19136968).
LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "RBCK1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1338CT | Recombinant Mouse anti-Human RBCK1 Monoclonal antibody (EML1092) | WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK1137 | Mouse Anti-RBCK1 Recombinant Antibody (clone UBCE7IP3) | WB | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6023 | Anti-RBCK1 Immunohistochemistry Kit | IHC |
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