Anti-REG4 (clone 12E1.3C11) Recombinant Antibody Coupled Liposome (VS-1024-FY150)
CAT#: VS-1024-FY150
Anti-REG4 antibody-conjugated liposomes are expected to achieve targeted therapy in colorectal cancer, as REG4 overexpression is closely associated with tumor progression. By utilizing specifically conjugated liposomes, drug selectivity towards tumor cells can be enhanced, potentially reducing side effects.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25867/57485_B_9_5.jpg
Normal Tissue
Figure 2 High expression in small intestine
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25867/57485_A_5_2.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25867/57485_A_8_3.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25867/57485_A_5_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134193-REG4
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More Infomation
Specifications
- Potential Clinical Applications
- Colorectal cancer
Product Composition
- Clone
- 12E1.3C11
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that was meticulously engineered to specifically target REG4, a protein associated with various pathological conditions. By selectively binding to REG4, this antibody holds promise for innovative therapeutic applications, potentially improving treatment outcomes for diseases where REG4 plays a critical role. The development of this targeted therapy exemplifies advances in biopharmaceutical research, paving the way for more personalized and effective medical interventions.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- REG4
- Introduction
- Reg protein belonging to the family of calcium-dependent lectin superfamily, according to the structure of the encoded proteins, Reg family can be divided into four subtypes, i.e. I, II, III, IV type, they have similar gene structure, contain 5 introns and 6 exons, the TATA box and CCAAT box located at 27 and 100bp encoding 158-175 amino acids in length, ranging from a secreted protein upstream of the transcription start site.
- Alternative Names
- Regenerating Family Member 4; Gastrointestinal Secretory Protein; Regenerating Islet-Derived Family, Member 4; Regenerating Islet-Derived Protein IV; Regenerating Gene Type IV; REG-Like Protein; Reg IV
- Full Name
- Regenerating Family Member 4
- Gene ID
- 83998
- UniProt ID
- Q9BYZ8
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn50 ( NX_Q9BYZ8 [NX_Q9BYZ8-1] )
Modification sites at PhosphoSitePlus ( Q9BYZ8 )
Glycosylation from GlyGen (Q9BYZ8) 1 site
- Protein Refseq
- NP_001152824.1; NP_001152825.1; NP_114433.1
- Function
- Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment.
May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone 12E1.3C11"
- CAT
- Product Name
See other products for "REG4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2593z | Mouse Anti-REG4 Recombinant Antibody (clone 43C1) | ELISA, WB | Mouse IgG2b |
| MOB-1791CT | Recombinant Mouse anti-Human REG4 Monoclonal antibody (NN0635-0C32) | WB | |
| HPAB-M0195-YC | Mouse Anti-REG4 Recombinant Antibody (clone D6) | ELISA | Mouse IgG |
| HPAB-M0196-YC | Mouse Anti-REG4 Recombinant Antibody (clone C9) | ELISA | Mouse IgG |
| HPAB-1604-FY | Human Anti-REG4 Recombinant Antibody (clone 3C2.3D10) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4392 | Hi-Affi™ Recombinant Rabbit Anti-REG4 Monoclonal Antibody (SI483DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0124-LSX-S(P) | Human Anti-REG4 Recombinant Antibody (clone 12E1.3C11); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-0125-LSX-S(P) | Mouse Anti-REG4 Recombinant Antibody (clone Reg4-G7); scFv Fragment | ELISA, WB, FC | Mouse scFv |
| HPAB-0126-LSX-S(P) | Mouse Anti-REG4 Recombinant Antibody (clone 21-1); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-M0195-YC-S(P) | Mouse Anti-REG4 Recombinant Antibody (clone D6); scFv Fragment | ELISA | Mouse scFv |
| HPAB-M0196-YC-S(P) | Mouse Anti-REG4 Recombinant Antibody (clone C9); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0124-LSX-F(E) | Human Anti-REG4 Recombinant Antibody (clone 12E1.3C11); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0125-LSX-F(E) | Mouse Anti-REG4 Recombinant Antibody (clone Reg4-G7); Fab Fragment | ELISA, WB, FC | Mouse Fab |
| HPAB-0126-LSX-F(E) | Mouse Anti-REG4 Recombinant Antibody (clone 21-1); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-M0195-YC-F(E) | Mouse Anti-REG4 Recombinant Antibody (clone D6); Fab Fragment | ELISA | Mouse Fab |
| HPAB-M0196-YC-F(E) | Mouse Anti-REG4 Recombinant Antibody (clone C9); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6071 | Anti-REG4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC276 | Recombinant Anti-REG4 Eliminating Antibody, pH-Sensitive (Reg4-G7 var.) | Antigen-Sweeping In Vivo. | Mouse IgG1 |
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