Mouse Anti-RNF4 Recombinant Antibody (VS3-FY2863)
CAT#: VS3-FY2863
The anti-RNF4 antibody is a mouse recombinant monoclonal antibody, which has been intricately crafted to target the human RNF4 protein. The calculated molecular weight of the protein is about 21.3 kDa. The antibody can be utilized for detection of RNF4 by Western Blot (1/500-1/2000).
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human RNF4
- Species Reactivity
- Human
- Applications
- Western Blot
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 21.3 kDa.
- Related Disease
- Ruijs-Aalfs Syndrome and Acute Promyelocytic Leukemia
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Target
- Alternative Names
- Ring Finger Protein 4; RING-Type E3 Ubiquitin Transferase RNF4; RING Finger Protein 4; SNURF; Small Nuclear RING Finger Protein; Small Nuclear Ring Finger Protein; E3 Ubiquitin-Protein Ligase RNF4
- Gene ID
- 6047
- UniProt ID
- P78317
- Cellular Localization
- Cytoplasm
Nucleus
- Post Translation Modifications
- Sumoylated; conjugated by one or two SUMO1 moieties. (P78317-RNF4_HUMAN)
Autoubiquitinated. (P78317-RNF4_HUMAN)
Ubiquitination at Lys168 (NX_P78317 [NX_P78317-1])
Modification sites at PhosphoSitePlus (P78317)
- Protein Refseq
- XP_054206669.1; NP_001171938.1; NP_001171939.1; NP_002929.1
- Function
- E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:18408734, 19307308, 35013556).
Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:18408734, 19307308, 20943951).
Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (PubMed:20212317).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "RNF4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1933 | Anti-RNF4 Immunohistochemistry Kit | IHC |
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