Recombinant Alpaca Anti-RTA Single Domain Antibody (PABC-569) (CAT#: PABC-569)
This product is a recombinant Alpaca antibody that can recognize RTA. V1C7 binds epitope(s) associated with weaker toxin neutralizing activity. V1C7's interface with RTA is limited to α-helix D (residues 141–142, 145–146, 149, and 153) and α-helix E (residue 163), along with several additional interactions with loops e-d (residues 65–68), C-D (residue 138), D-E (residues 157–160), and F-G (residues 195, 197).
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Figure 3 Relationships between VHH binding affinities and toxin-neutralizing activities.
Each color represents a family; each dot represents an individual VHH within that family. The downward slope of the lines suggests a relationship between KD and TNA within a clonal family.
Vance, D. J., Tremblay, J. M., Rong, Y., Angalakurthi, S. K., Volkin, D. B., Middaugh, C. R., ... & Mantis, N. J. (2017). High-resolution epitope positioning of a large collection of neutralizing and nonneutralizing single-domain antibodies on the enzymatic and binding subunits of ricin toxin. Clin. Vaccine Immunol., 24(12), e00236-17.
ELISA
Figure 4 4 Validation of cross-competition ELISA as a strategy for epitope localization on RTA.
V1C7 were subjected to competition ELISAs with a panel of RTA-specific MAbs representing neutralizing clusters I to IV.
Vance, D. J., Tremblay, J. M., Rong, Y., Angalakurthi, S. K., Volkin, D. B., Middaugh, C. R., ... & Mantis, N. J. (2017). High-resolution epitope positioning of a large collection of neutralizing and nonneutralizing single-domain antibodies on the enzymatic and binding subunits of ricin toxin. Clin. Vaccine Immunol., 24(12), e00236-17.
Specifications
- Host Species
- Alpaca
- Type
- Alpaca VHH
- Specificity
- RTA
- Species Reactivity
- Castor bean
- Clone
- PABC-569
- Applications
- ELISA, FC, Neut
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for ELISA, Flow Cytometry, Neutralization. For details, refer to Published Data.
Target
- Alternative Names
- Ricin A chain; Ricin; RTA; Ricinus communis
- UniProt ID
- P02879
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single Domain Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-567 | Recombinant Alpaca Anti-RTA Single Domain Antibody (PABC-567) | ELISA, FC, Neut | Alpaca VHH |
| PABC-568 | Recombinant Llama Anti-RTA Single Domain Antibody (PABC-568) | ELISA, WB, Neut | Llama VHH |
| PABC-570 | Recombinant Alpaca Anti-RTA Single Domain Antibody (PABC-570) | ELISA, FC, Neut | Alpaca VHH |
| PABC-571 | Recombinant Alpaca Anti-RTA Single Domain Antibody (PABC-571) | ELISA, Neut | Alpaca VHH |
| PABJ-0033 | Camelid Anti-RTA Recombinant Antibody (PABJ-0033) | ELISA, Neut | Camelid VHH |
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