Mouse Anti-SCARB2 Recombinant Antibody (clone JL2) (CAT#: PABS-0248)
This recombinant monoclonal antibody to Human SCARB2 is a Mouse monoclonal antibody that can be used for applications: ELISA, Block, Inhib. This product can effectively inhibit EV71 infection of target cells.
Specific Inquiry
WB
Figure 1 The monoclonal antibody JL2 binds human SCARB2.
Cells overexpressing human SCARB2 and SCARB2 knockout cells were lysed and analyzed by Western blot using the anti-human SCARB2 polyclonal antibody (pAb) (top panel) and JL2 (middle panel). The lowest panel: β-actin was used as a loading control.
Zhang, X., Yang, P., Wang, N., Zhang, J., Li, J., Guo, H., ... & Zhang, L. (2017). The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. Protein & cell, 8(8), 590-600.
FC
Figure 2 The monoclonal antibody JL2 binds human SCARB2.
Surface staining of 293-hSCARB2 cells. Open area represents staining with JL2 and shaded area represents isotype control staining.
Zhang, X., Yang, P., Wang, N., Zhang, J., Li, J., Guo, H., ... & Zhang, L. (2017). The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. Protein & cell, 8(8), 590-600.
FC
Figure 3 The monoclonal antibody JL2 binds human SCARB2.
The binding of 293-hSCARB2 cells with different concentrations of JL2 (square) and the IgG2a isotype control (circle)
Zhang, X., Yang, P., Wang, N., Zhang, J., Li, J., Guo, H., ... & Zhang, L. (2017). The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. Protein & cell, 8(8), 590-600.
Block
Figure 4 JL2 blocks EV71 infection.
GFP-positive cell counts among 293-hSCARB2 cells pretreated with JL2 (square) or the isotype control (circle) before EV71-GFP infection. The data are shown as the mean ± SEM of triplicates.
Zhang, X., Yang, P., Wang, N., Zhang, J., Li, J., Guo, H., ... & Zhang, L. (2017). The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. Protein & cell, 8(8), 590-600.
Block
Figure 5 JL2 blocks EV71 infection.
The replication of wild type EV71 in 293-hSCARB2 cells in the presence of JL2 (2 μg/mL) or isotype control.
Zhang, X., Yang, P., Wang, N., Zhang, J., Li, J., Guo, H., ... & Zhang, L. (2017). The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. Protein & cell, 8(8), 590-600.
Specifications
- Immunogen
- hSCARB2-transfected L929 cells
- Host Species
- Mouse
- Derivation
- Hybridoma cell line
- Type
- Mouse IgG2a
- Specificity
- Human SCARB2
- Species Reactivity
- Human
- Clone
- JL2
- Applications
- ELISA, Block, Inhib
- Related Disease
- Action myoclonus renal failure syndrome, Proteinuria, Kidney failure, Focal segmental glomerulosclerosis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- AMRF; EPM4; LGP85; CD36L2; HLGP85; LIMP-2; LIMPII; SR-BII
- Gene ID
- 950
- UniProt ID
- Q14108
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Rabbit Monoclonal Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3180 | Hi-Affi™ Recombinant Rabbit Anti-SCARB2 Monoclonal Antibody (DS3180AB) | WB, FC, IP, IHC-P | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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