Rabbit Anti-Seh1L Recombinant Antibody (clone R03-9E2) (CAT#: VS3-FY1878)

• Immunogen
• Synthetic peptide of mouse SEH1L

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat Seh1L

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R03-9E2

• Applications
• Western Blot, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 40 kDa, while the observed molecular weight stands at 40 kDa.

• Related Disease
• Nail Disorder, Nonsyndromic Congenital, 4 and Nonsyndromic Congenital Nail Disorder

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunoprecipitation: 1/20

• Alternative Names
• SEH1 Like Nucleoporin; Nup107-160 Subcomplex Subunit SEH1; GATOR Complex Protein SEH1; Sec13 Like Protein; SEC13-Like Protein; SEC13L; Seh1

• Gene ID
• 72124

• UniProt ID
• Q8R2U0

• Sequence Similarities
• Belongs to the WD repeat SEC13 family.

• Cellular Localization
• Centromere, Chromosome, Kinetochore, Lysosome, Membrane

• Post Translation Modifications
• Ubiquitination at Lys12, Lys96, Lys306, and Lys314 (NX_Q96EE3 [NX_Q96EE3-2])
  Modification sites at PhosphoSitePlus (Q96EE3)
  Glycosylation from GlyGen (Q96EE3) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_005258209.1; XP_011524044.1; XP_011524045.1; XP_011524046.1; XP_016881514.1

• Function
• Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody