Rabbit Anti-SNAP25 Recombinant Antibody (clone R01-1C6) (CAT#: VS3-FY1882)

• Immunogen
• Synthetic peptide of human SNAP25

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat SNAP25

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R01-1C6

• Applications
• Western Blot

• MW
• The calculated weight of the target protein is approximately 23 kDa, while the observed molecular weight stands at 23 kDa.

• Related Disease
• Myasthenic Syndrome, Congenital, 18 and Presynaptic Congenital Myasthenic Syndromes

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• Synaptosome Associated Protein 25; Resistance To Inhibitors Of Cholinesterase 4 Homolog; Synaptosomal-Associated Protein, 25kDa; SNAP-25; SNAP; SUP; Synaptosomal-Associated 25 KDa Protein; Synaptosome Associated Protein 25kDa; Synaptosomal-Associated Protein 25

• Gene ID
• 6616

• UniProt ID
• P60880

• Sequence Similarities
• Belongs to the SNAP-25 family.

• Cellular Localization
• Cell membrane, Cytoplasm, Membrane, Synapse, Synaptosome

• Post Translation Modifications
• Palmitoylated (PubMed:28757145)., Cys-85 appears to be the main site, and palmitoylation is required for membrane association ()., (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type A (BoNT/A, botA) which hydrolyzes the 197-Gln-|-Arg-198 bond and inhibits neurotransmitter release (PubMed:15592454, PubMed:9886085)., (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type C (BoNT/C) which hydrolyzes the 198-Arg-|-Ala-199 bond and inhibits neurotransmitter release (PubMed:9886085, PubMed:17718519)., C.botulinum type C only rarely infects humans., (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type E (BoNT/E) which hydrolyzes the 180-Arg-|-Ile-181 bond and inhibits neurotransmitter release (PubMed:9886085).

• Protein Refseq
• NP_001309831.1; NP_001309832.1; NP_001309833.1

• Function
• t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody