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  • Rabbit Anti-SNRPA1 Recombinant Antibody (clone R69-2F-4)

Rabbit Anti-SNRPA1 Recombinant Antibody (clone R69-2F-4) (CAT#: VS3-FY2144)

Clone R69-2F-4 is a rabbit recombinant antibody that exhibits high affinity to human SNRPA1 protein, a calculated weight of 28 kDa. It cross-reacts with mouse, rat.
The following recommendations serve as a starting point for assay optimization. The actual working concentration may vary and should be determined by the user. The R69-2F-4 is recommended for detection of target protein by western blotting (dilution range 1:500-1:1000), immunohistochemistry (dilution range 1:100-1:200).


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Specific Inquiry
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  • Gene Expression
  • Datasheet
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  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45622/if_selected.jpg
Figure 2 IF staining of human cell line RT4
Figure 2 IF staining of human cell line RT4
(Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm & nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48499/1748_E10_21_cr5805e23dd222d_selected.jpg
Normal Tissue
Figure 3 IHC staining of human stomach, upper
Figure 3 IHC staining of human stomach, upper
(Immunohistochemical staining of human stomach, upper shows strong nuclear positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45622/ihc_selected.jpg
Figure 4 Testis
Figure 4 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45622/103223_A_5_6.jpg
Figure 5 Lymph node
Figure 5 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45622/103223_A_7_8.jpg
Figure 6 Colon
Figure 6 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45622/103223_A_9_3.jpg
Figure 7 Liver
Figure 7 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45622/103223_A_7_4.jpg
Figure 8 Pancreas
Figure 8 Pancreas
(Exocrine glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Pancreatic endocrine cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45622/103223_A_2_3.jpg
Figure 9 Kidney
Figure 9 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45622/103223_A_9_5.jpg
RNA Expression
Figure 10 RNA cell line category: Low cell line specificity
Figure 10 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131876-SNRPA1

Specifications

  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Mouse and Rat SNRPA1
  • Species Reactivity
  • Human, Mouse, Rat
  • Clone
  • R69-2F-4
  • Applications
  • Western Blot, Immunohistochemistry-Paraffin
  • Conjugate
  • Unconjugated
  • MW
  • The calculated weight of the target protein is approximately 28 kDa, while the observed molecular weight stands at 28kDa.
  • Related Disease
  • Primary Optic Atrophy and Galloway-Mowat Syndrome 1

Product Property

  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS (pH 7.4), 150 mM NaCl, 50% glycerol
  • Preservative
  • 0.02% Sodium azide
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Western Blot: 1/500-1/1000
    Immunohistochemistry: 1/100-1/200

Target

  • Alternative Names
  • Small Nuclear Ribonucleoprotein Polypeptide A'; Small Nuclear Ribonucleoprotein Polypeptide A; U2 SnRNP A; U2 Small Nuclear Ribonucleoprotein Polypeptide A; U2 Small Nuclear Ribonucleoprotein A; Lea1
  • Sequence Similarities
  • Belongs to the U2 small nuclear ribonucleoprotein A family.
  • Cellular Localization
  • Nucleus, Spliceosome
  • Post Translation Modifications
  • Ubiquitination at Lys149, Lys179, Lys205, and Lys221 (NX_P09661 [NX_P09661-1])
    Modification sites at PhosphoSitePlus (P09661)
    Glycosylation from GlyGen (P09661) 1 site, 1 O-linked glycan (1 site)
  • Function
  • Involved in pre-mRNA splicing as component of the spliceosome.
    Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA.

Recommended Products

Isotype Control

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "SNRPA1"

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3358 Hi-Affi™ Recombinant Rabbit Anti-SNRPA1 Monoclonal Antibody (DS3358AB) WB, IHC IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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