AbPlus™ Anti-SUMO1 Magnetic Beads (VS-0724-YC1166)
CAT#: VS-0724-YC1166
The AbPlus Anti-SUMO1 Magnetic Beads (VS-0724-YC1166) is an innovative affinity resin which is bound with anti-SUMO1 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of SUMO1 protein under native and denaturing conditions.
Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-SUMO1 specific antibody
- Target
- SUMO1
- Immunogen
- Recombinant human SUMO1/SUMO-1, aa 2-101.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability.
- Alternative Names
- DAP1; GMP1; PIC1; SMT3; UBL1; OFC10; SENP2; SMT3C; SMT3H3
- Gene ID
- 7341
- UniProt ID
- P63165
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Captured SUMOylated Proteins
Detecting SUMOylation is always tricky due to its transient nature, but these beads worked wonders. We were able to enrich SUMO1 modified proteins from our cell extracts effectively, making the bands visible in our western blots where they were previously undetectable.
Robust Binding Affinity
The antibody conjugated to these beads has high affinity. Even with stringent washing steps to reduce background, we still retained a significant amount of the SUMOylated targets, which speaks to the quality of the conjugation and the antibody itself.
Q&As
-
Why are these beads useful for studying protein SUMOylation?
A: SUMOylation is a transient and often low-abundance post-translational modification. These beads are conjugated with a high-affinity anti-SUMO1 antibody, allowing for the efficient enrichment and immunoprecipitation of SUMO1-modified proteins from complex cell lysates, which facilitates their detection and identification.
-
Can I use these beads to identify novel SUMO1 substrates?
A: Yes, by enriching for SUMO1-containing proteins using these beads, you can perform downstream analyses such as mass spectrometry. This approach is powerful for discovering new substrates of the SUMOylation pathway and understanding their roles in cellular processes like DNA repair and cell cycle regulation.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "SUMO1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0267MC | Recombinant Anti-SUMO-1 Antibody | WB, IP, IF, IHC(P), ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0413ZL | Goat anti-Human SUMO-1 Antibody | WB, IP, IF, ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-603NL | Recombinant Anti-Human SUMO1 Antibody | WB, ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1981CT | Recombinant Mouse anti-Human SUMO1 Monoclonal antibody (opof) | ICC, IF, IP, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3460 | Hi-Affi™ Recombinant Rabbit Anti-SUMO1 Monoclonal Antibody (DS3460AB) | WB, IHC-P, ICC, IF, FC, IP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1452-CN | Recombinant Rabbit Anti-SUMO1 Monoclonal Antibody (CBACN-538) | WB, IF, IHC, IP, FC, ChIP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY496 | Rabbit Anti-NHP SUMO1 Recombinant Antibody (VS-1024-XY496) | WB, IHC, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC1130 | CytoStream™ Rabbit Anti-SUMO1 Recombinant Antibody (VS13-YC1130) | WB, ICC, IF, IHC-P, IP, FC, ChIP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2228 | Anti-SUMO1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7021 | Anti-Mouse SUMO1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7020 | Anti-Human SUMO1 Immunohistochemistry Kit | IHC |
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