Anti-SYT1 (clone W24V129) Recombinant Antibody Coupled Liposome (VS-1024-FY131)
CAT#: VS-1024-FY131
Anti-S100A10 antibodies that are bound to liposomes represent a promising strategy in glioma research, as they can specifically target tumor cells while minimizing off-target effects. S100A10 is believed to play a crucial role in the regulation of immune responses within the glioma microenvironment, thus influencing tumor growth and progression. By utilizing liposomes as a drug delivery system, the therapeutic efficacy of these antibodies may be significantly enhanced, allowing for sustained release and improved bioavailability at the tumor site. This innovative approach could not only advance our understanding of glioma biology but also pave the way for more effective treatment modalities in combating this challenging form of brain cancer.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8394/142559_B_8_5.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (hTERT-HME1, hTERT-RPE1, LHCN-M2, SH-SY5Y, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000067715-SYT1/subcellular
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V129
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that has been engineered to specifically recognize and bind to the human SYT1 protein. The unique properties of this antibody make it an invaluable tool for researchers studying the functions and mechanisms of SYT1 in various biological processes. By targeting this specific protein, the antibody can aid in elucidating the role of SYT1 in disease states and potential therapeutic applications.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- SYT1
- Introduction
- Enables several functions, including calmodulin binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in several processes, including positive regulation of dopamine secretion; regulation of vesicle-mediated transport; and response to calcium ion. Located in several cellular components, including excitatory synapse; neuron projection terminus; and secretory vesicle. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of synaptic vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SYT1 (synaptotagmin 1).
- Alternative Names
- P65
- Full Name
- synaptotagmin 1
- Gene ID
- 6857
- UniProt ID
- P21579
- Sequence Similarities
- Belongs to the synaptotagmin family.
- Cellular Localization
- Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein; Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein; Cytoplasm
- Post Translation Modifications
- Glycosylated. ( P21579-SYT1_HUMAN )
Glycosylation at Asn25 ( NX_P21579 [NX_P21579-1] )
Modification sites at PhosphoSitePlus ( P21579 )
Glycosylation from GlyGen (P21579) 1 site, 1 N-linked glycan (1 site)
- Protein Refseq
- XP_047285435.1; XP_047285436.1; XP_047285437.1; XP_047285438.1; XP_047285439.1
- Function
- Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity).
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity).
It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported.
It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Plays a role in dendrite formation by melanocytes.
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Datasheet
MSDS
COA
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See other products for "SYT1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3883z | Mouse Anti-SYT1 Recombinant Antibody (clone 14H2) | ELISA, IHC, WB | Mouse IgG2a, κ |
| MOB-1973MZ | Recombinant Mouse Anti-Rat SYT1 Antibody (clone BTW40) | ICC, IF, WB | Mouse antibody |
| VS3-QX1080 | Mouse Anti-SYT1 Recombinant Antibody (clone 8G11B10) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS-0223-WK72 | Rabbit Anti-SYT1 Recombinant Antibody (VS-0223-WK72) | WB, IP, ICC, IHC, IHC-P | Rabbit IgG |
| VS-0223-WK73 | Rabbit Anti-SYT1 Recombinant Antibody (VS-0223-WK73) | WB, IP, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0732MZ | Chicken Anti-SYT1 Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2237 | Anti-SYT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7057 | Anti-Rat SYT1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC58 | Recombinant Anti-SYT1 Vesicular Antibody, EV Displayed (VS-0425-YC58) | ELISA, FC, Cell-uptake |
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