Anti-SYT1 (clone W24V129) Recombinant Antibody Coupled Liposome (VS-1024-FY131) (CAT#: VS-1024-FY131)

• Potential Clinical Applications
• Glioma

• Clone
• W24V129

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody that has been engineered to specifically recognize and bind to the human SYT1 protein. The unique properties of this antibody make it an invaluable tool for researchers studying the functions and mechanisms of SYT1 in various biological processes. By targeting this specific protein, the antibody can aid in elucidating the role of SYT1 in disease states and potential therapeutic applications.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• SYT1

• Introduction
• Enables several functions, including calmodulin binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in several processes, including positive regulation of dopamine secretion; regulation of vesicle-mediated transport; and response to calcium ion. Located in several cellular components, including excitatory synapse; neuron projection terminus; and secretory vesicle. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of synaptic vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SYT1 (synaptotagmin 1).

• Alternative Names
• P65

• Full Name
• synaptotagmin 1

• Gene ID
• 6857

• UniProt ID
• P21579

• Sequence Similarities
• Belongs to the synaptotagmin family.

• Cellular Localization
• Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein; Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein; Cytoplasm

• Post Translation Modifications
• Glycosylated. ( P21579-SYT1_HUMAN )
  Glycosylation at Asn25 ( NX_P21579 [NX_P21579-1] )
  Modification sites at PhosphoSitePlus ( P21579 )
  Glycosylation from GlyGen (P21579) 1 site, 1 N-linked glycan (1 site)

• Protein Refseq
• XP_047285435.1; XP_047285436.1; XP_047285437.1; XP_047285438.1; XP_047285439.1

• Function
• Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity).
  May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity).
  It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
  A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported.
  It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
  Plays a role in dendrite formation by melanocytes.

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