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SYT1
Enables several functions, including calmodulin binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in several processes, including positive regulation of dopamine secretion; regulation of vesicle-mediated transport; and response to calcium ion. Located in several cellular components, including excitatory synapse; neuron projection terminus; and secretory vesicle. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of synaptic vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SYT1 (synaptotagmin 1).
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Bipolar cells, Rod photoreceptor cells, Cone photoreceptor cells)
Immune cell specificity
Immune cell enhanced (naive B-cell, memory B-cell)
Cell line specificity
Cell line enhanced (hTERT-HME1, hTERT-RPE1, LHCN-M2, SH-SY5Y, WM-115)
Interaction
Homotetramer (Probable). Interacts with SCAMP5 (PubMed:19234194). Interacts with STON2 (PubMed:11381094). Forms a complex with SV2B, syntaxin 1 and SNAP25 (By similarity). Interacts with SV2A, SV2B and SV2C (By similarity). Interacts with RIMS1 (By similarity). Interacts with PRRT2 (By similarity). Interacts with DNAJC5 in a phosphorylation-dependent manner (By similarity). Interacts (via N-terminus) with RAB3A (By similarity). Interacts with SYT12 (By similarity). Interacts with calmodulin (By similarity).
More Types Infomation
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- Species Reactivity: Rat
- Type: Mouse antibody
- Application: ICC/IF, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: ELISA, IHC, WB
- Chicken Anti-SYT1 Polyclonal IgY (BRD-0732MZ)
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- Species Reactivity: Human, Rat, Mouse
- Type: Chicken antibody
- Application: ICC/IF, IHC, WB
- Guinea pig Anti-SYT1 Recombinant Antibody (VS-0223-WK75) (VS-0223-WK75)
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- Derivation: Guinea pig
- Species Reactivity: Rat, Mouse, Human, Zebrafish
- Type: Guinea pig IgG
- Application: WB, ICC, IHC, IHC-P
- Rabbit Anti-SYT1 Recombinant Antibody (VS-0223-WK74) (VS-0223-WK74)
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- Derivation: Rabbit
- Species Reactivity: Rat
- Type: Rabbit IgG
- Application: ICC
- Rabbit Anti-SYT1 Recombinant Antibody (VS-0223-WK73) (VS-0223-WK73)
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- Derivation: Rabbit
- Species Reactivity: Rat
- Type: Rabbit IgG
- Application: WB, IP, IHC
- Rabbit Anti-SYT1 Recombinant Antibody (VS-0223-WK72) (VS-0223-WK72)
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- Derivation: Rabbit
- Species Reactivity: Rat, Mouse, Human, Zebrafish
- Type: Rabbit IgG
- Application: WB, IP, ICC, IHC, IHC-P
- Mouse Anti-SYT1 Recombinant Antibody (clone 8G11B10) (VS3-QX1080)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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For Research Use Only. Not For Clinical Use.