Anti-TNFSF13 Antibody Prodrug, Protease Activated (VS-1025-YC160)
CAT#: VS-1025-YC160
The Anti-TNFSF13 Antibody Prodrug, Protease Activated (VS-1025-YC160) is an antibody prodrug comprised of a recombinant mouse antibody targeting human TNFSF13, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to TNFSF13 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to TNFSF13 effectively. TNFSF13 (APRIL) is a TNF superfamily ligand that promotes the survival and proliferation of malignant B-cells and plasma cells. High expression of APRIL in the tumor microenvironment is a key survival factor in multiple myeloma and B-cell lymphomas.
Gene Expression
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (EFO-21, RPMI-8226, RPTEC TERT1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000161955-TNFSF13
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4863/13948_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4863/13948_A_7_3.jpg
Normal Tissue
Figure 3 Pancreas
Exocrine glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4863/13948_A_2_3.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4863/13948_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (EFO-21, RPMI-8226, RPTEC TERT1, U-937)
Cell lines ordered by descending RNA expression order.
❮
❯
Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human TNFSF13
- Target
- TNFSF13
- Species Reactivity
- Human, Mouse
- Isotype
- IgG, kappa
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
- Alternative Names
- APRIL; CD256; TALL2; ZTNF2; TALL-2; TNLG7B; TRDL-1; UNQ383/PRO715
- Gene ID
- 8741
- UniProt ID
- O75888
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-953 | Mouse Anti-Tnfsf13 Recombinant Antibody (clone Apry-1-1) | ELISA, IP | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-954 | Mouse Anti-Tnfsf13 Recombinant Antibody (clone Apry-1-1), Biotin | ELISA, IP | Mouse IgG |
| CAT | Product Name | Application | Type |
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| DrMAB-977 | Recombinant Mouse Anti-Mouse Tnfsf13 Antibody, clone Apry-1-1 | ELISA, IP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0692MZ | Recombinant Mouse Anti-Human TNFSF13 Antibody (clone Bqsjmz-2) | FC, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2124CQ | Mouse Anti-TNFSF13 Recombinant Antibody (clone CBL818) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3621 | Rabbit Anti-TNFSF13 Recombinant Antibody (clone DS3621AB) | WB, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0040CQ | Mouse Anti-TNFSF13 Recombinant Antibody (HPAB-0040CQ) | ELISA, Neut | Mouse IgG, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0040CQ-S(P) | Mouse Anti-TNFSF13 Recombinant Antibody; scFv Fragment (HPAB-0040CQ-S(P)) | ELISA, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0041CQ-S(P) | Mouse Anti-TNFSF13 Recombinant Antibody scFv Fragment (HPAB-0041CQ-S(P)) | ELISA, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0042CQ-S(P) | Mouse Anti-TNFSF13 Recombinant Antibody scFv Fragment (HPAB-0042CQ-S(P)) | ELISA, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0044CQ-S(P) | Human Anti-TNFSF13 Recombinant Antibody; scFv Fragment (HPAB-0044CQ-S(P)) | ELISA, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045CQ-S(P) | Mouse Anti-TNFSF13 Recombinant Antibody scFv Fragment (HPAB-0045CQ-S(P)) | ELISA, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0040CQ-F(E) | Mouse Anti-TNFSF13 Recombinant Antibody; Fab Fragment (HPAB-0040CQ-F(E)) | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0041CQ-F(E) | Mouse Anti-TNFSF13 Recombinant Antibody Fab Fragment (HPAB-0041CQ-F(E)) | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0042CQ-F(E) | Mouse Anti-TNFSF13 Recombinant Antibody Fab Fragment (HPAB-0042CQ-F(E)) | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0043CQ-F(E) | Human Anti-TNFSF13 Recombinant Antibody Fab Fragment (HPAB-0043CQ-F(E)) | ELISA, Neut | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0044CQ-F(E) | Human Anti-TNFSF13 Recombinant Antibody; Fab Fragment (HPAB-0044CQ-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7393 | Anti-TNFSF13 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC317 | Recombinant Anti-TNFSF13 Eliminating Antibody, pH-Sensitive (VS-0625-YC317) | Antigen-Sweeping In Vivo. | Mouse IgG1 kappa |
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