Anti-TP63 Antibody Prodrug, Protease Activated (VS-1025-YC82)
CAT#: VS-1025-YC82
The Anti-TP63 Antibody Prodrug, Protease Activated (VS-1025-YC82) is an antibody prodrug comprised of a recombinant mouse antibody targeting human TP63, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to TP63 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to TP63 effectively. TP63 is a transcription factor structurally related to the tumor suppressor p53, and its function is highly context-dependent. Its overexpression often acts as an oncogene in squamous cell carcinomas of the lung, head, and neck. Conversely, it is necessary for maintaining the integrity of squamous epithelia.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6289/1843_E1_9_cr5af96f44b42f8_selected.jpg
Normal Tissue
Figure 2 Skin 1
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6288/19019_B_7_1_val_selected.jpg
Normal Tissue
Figure 3 Skin
Cells in basal layer Staining: High Intensity: Strong Quantity:>75% Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Cells in spinous layer Staining: High Intensity: Strong Quantity: 75%-25% Eccrine glands Staining: High Intensity: Strong Quantity: 75%-25% Hair follicles Staining: High Intensity: Strong Quantity: 75%-25% Sebaceous glands Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/83/860_B_9_1.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/83/860_A_7_8.jpg
Normal Tissue
Figure 5 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/83/860_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073282-TP63
❮
❯
Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human TP63
- Target
- TP63
- Species Reactivity
- Human
- Isotype
- IgG1, kappa
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein G purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- TP63 encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in TP63 are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.
- Alternative Names
- AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP
- Gene ID
- 8626
- UniProt ID
- Q9H3D4
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1025-YC82. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "TP63"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1466z | Mouse Anti-TP63 Recombinant Antibody (clone 8H11) | WB, IHC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1516CT | Recombinant Mouse anti-Human TP63 Monoclonal antibody (98D664) | WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3647 | Rabbit Anti-TP63 Recombinant Antibody (clone DS3647AB) | ICC, IF, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1156-CN | Rabbit Anti-TP63 Recombinant Antibody (clone CBACN-419) | WB, IF, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2104-CN | Rabbit Anti-TP63 Polyclonal Antibody (MRO-2104-CN) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0411-YJ | Mouse Anti-TP63 Recombinant Antibody (HPAB-0411-YJ) | ELISA, WB, DB, IHC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0411-YJ-S(P) | Mouse Anti-TP63 Recombinant Antibody; scFv Fragment (HPAB-0411-YJ-S(P)) | ELISA, WB, DB, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0411-YJ-F(E) | Mouse Anti-TP63 Recombinant Antibody; Fab Fragment (HPAB-0411-YJ-F(E)) | ELISA, WB, DB, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX1161 | Mouse Anti-TP63 Recombinant Antibody (clone 603CT12.4.3) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2332 | Anti-TP63 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7448 | Anti-Mouse TP63 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7447 | Anti-Human TP63 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7449 | Anti-Rat TP63 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: Neut, Inhib, FC, ELISA
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, Inhib, FuncS
Application: ELISA, Inhib, FC, Neut
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
