Human Anti-TPI 1 Recombinant Antibody (clone CSF) (CAT#: FAMAB-0289YC)
TPI is glycolytic enzyme essential for efficient energy production and are expressed in all prokaryotic and eukaryotic organisms. TPI and GAPDH have been considered to associate with brain microtubules. The anti-TPI or anti-GAPDH Abs may induce an immune hypersensitivity reaction, through activation of complements and macrophages, leading to neuronal and axonal degeneration in MS.
Specific Inquiry
WB
Figure 1 TPI- and GAPDH-reactive Abs in the CSF of MS patients.
Western blot using CSF samples from MS patients and a negative control without CSF.
Kolln, J., Ren, H. M., Da, R. R., Zhang, Y., Spillner, E., Olek, M., Hermanowicz, N., Hilgenberg, L. G., Smith, M. A., van den Noort, S., & Qin, Y. (2006). Triosephosphate isomerase- and glyceraldehyde-3-phosphate dehydrogenase-reactive autoantibodies in the cerebrospinal fluid of patients with multiple sclerosis. Journal of immunology (Baltimore, Md.: 1950), 177(8), 5652–5658.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human TPI 1
- Species Reactivity
- Human
- Clone
- CSF
- Applications
- ELISA, WB
- Related Disease
- Multiple sclerosis
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0289-YC-S(P) | Human Anti-TPI 1 Recombinant Antibody (clone CSF); scFv Fragment | ELISA, WB | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0289-YC-F(E) | Human Anti-TPI 1 Recombinant Antibody (clone CSF); Fab Fragment | ELISA, WB | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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