Rabbit Anti-TRAM2 Recombinant Antibody (clone R01-7F4)
CAT#: VS3-XY3530
The recombinant rabbit antibody reacts with TRAM2 (Translocation associated membrane protein 2), which is necessary for collagen type I synthesis. This antibody specifically reacts with human, mouse and rat TRAM2. It has been tested using Western Blot. The recommended dilutions of Western Blot is 1/500-1/1000.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35092/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human rectum
Immunohistochemical staining of human rectum shows moderate cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57925/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57925/142894_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57925/142894_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57925/142894_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000065308-TRAM2
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat TRAM2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R01-7F4
- Applications
- WB
- Related Disease
- Epilepsy; Myoclonic Juvenile
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- Translocation associated membrane protein 2
- Gene ID
- 9697
- UniProt ID
- Q15035
- Long Name
- Translocation associated membrane protein 2
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn55 (NX_Q15035 [NX_Q15035-1])
Modification sites at PhosphoSitePlus (Q15035)
Glycosylation from GlyGen (Q15035) 1 site
- Protein Refseq
- XP_054212856.1; XP_011513307.1
- Function
- Necessary for collagen type I synthesis.
May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon.
This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding.
Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT).
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Related Signaling Pathways
TLR Signaling Pathway
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Recommended Dilution Buffer
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Secondary Antibody
- CAT
- Product Name
See other products for "TRAM2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3673 | Rabbit Anti-TRAM2 Recombinant Antibody (clone DS3673AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7494 | Anti-TRAM2 Immunohistochemistry Kit | IHC |
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