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  • Rabbit Anti-TRIM21 Recombinant Antibody (VS3-FY2906)

Rabbit Anti-TRIM21 Recombinant Antibody (VS3-FY2906) (CAT#: VS3-FY2906)

The anti-TRIM21 product is a recombinant rabbit monoclonal antibody that binds to human TRIM21 protein. This monoclonal antibody is suitable for conducting research on Lupus Erythematosus and Sjogren Syndrome. The optimal dilution for this antibody is Western Blot (1/500-1/1000).

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Formats:
  • Isotype Switching:
  • Fc Engineering:
  • Modalities:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line HUVEC TERT2
Figure 1 IF staining of human cell line HUVEC TERT2
(Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/1752_A4_4_cr581104495f16e_selected.jpg
Figure 2 IHC staining of human gallbladder
Figure 2 IHC staining of human gallbladder
(Immunohistochemical staining of human gallbladder shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_5_4_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/38_D11_1_red_green.jpg
Figure 4 IF staining of human cell line U-251 MG
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/40_D11_1_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Figure 5 Cerebral cortex
(Neuronal cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_B_7_5.jpg
Figure 6 Colon
Figure 6 Colon
(Glandular cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Peripheral nerve/ganglion
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_9_3.jpg
Figure 7 Liver
Figure 7 Liver
(Cholangiocytes
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_9_4.jpg
Figure 8 Kidney
Figure 8 Kidney
(Cells in tubules
Staining:

High

Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_8_5.jpg
Figure 9 Testis
Figure 9 Testis
(Leydig cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_5_6.jpg
Figure 10 Placenta
Figure 10 Placenta
(Trophoblastic cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_1_7.jpg
Figure 11 Lymph node
Figure 11 Lymph node
(Non-germinal center cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_9_8.jpg
RNA Expression
Figure 12 RNA cell line category: Low cell line specificity
Figure 12 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000132109-TRIM21
Figure 12 RNA cell line category: Low cell line specificity
Figure 12 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132109-TRIM21

Specifications

  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human TRIM21
  • Species Reactivity
  • Human
  • Applications
  • Western Blot
  • Conjugate
  • Unconjugated, FITC
  • Related Disease
  • Lupus Erythematosus and Sjogren Syndrome

Product Property

  • Clonality
  • Monoclonal Antibody
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Western Blot: 1/500-1/1000

Target

  • Alternative Names
  • Tripartite Motif Containing 21; Sjogren Syndrome Antigen A1 (52kDa, Ribonucleoprotein Autoantigen SS-A/Ro); 52 KDa Ribonucleoprotein Autoantigen Ro/SS-A; RING-Type E3 Ubiquitin Transferase TRIM21; Tripartite Motif-Containing Protein 21; Sjoegren Syndrome Type A Antigen; RING Finger Protein 81; 52 KDa Ro Protein; Ro(SS-A); RNF81
  • Sequence Similarities
  • Belongs to the TRIM/RBCC family.
  • Cellular Localization
  • Cytoplasm
    Cytoplasmic vesicle, autophagosome
    Nucleus
    Cytoplasm, P-body
    Cytoplasm, Stress granule
  • Post Translation Modifications
  • Autoubiquitinated; does not lead to its proteasomal degradation.
    Deubiquitinated by USP4; leading to its stabilization.
    (P19474-RO52_HUMAN)
    Ubiquitination at Lys260 (NX_P19474 [NX_P19474-1])
    Modification sites at PhosphoSitePlus (P19474)
    Glycosylation from GlyGen (P19474) 1 site, 1 O-linked glycan (1 site)
  • Function
  • Plays a role in the regulation of the cell cycle progression (PubMed:16880511).
    Enhances the decapping activity of DCP2 (PubMed:18361920).
    Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules.

Recommended Products

Secondary Antibody

Isotype Control

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "TRIM21"

Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products Fab Antibody Products ScFv Antibody Products
CAT Product Name Application Type
MOB-1189z Mouse Anti-TRIM21 Recombinant Antibody (clone 20C4) WB, ELISA Mouse IgG1
FAMAB-0007JF Chicken Anti-TRIM21 Recombinant Antibody (clone R2E5) WB, Neut, Inhib, FuncS, IHC
VS3-QX1165 Mouse Anti-TRIM21 Recombinant Antibody (clone 5B9-B9-H8) WB Mouse IgG1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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