Rabbit Anti-TRIM21 Recombinant Antibody (VS3-FY2906)
CAT#: VS3-FY2906
The anti-TRIM21 product is a recombinant rabbit monoclonal antibody that binds to human TRIM21 protein. This monoclonal antibody is suitable for conducting research on Lupus Erythematosus and Sjogren Syndrome. The optimal dilution for this antibody is Western Blot (1/500-1/1000).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HUVEC TERT2
Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/1752_A4_4_cr581104495f16e_selected.jpg
Subcellular Location
Figure 2 IHC staining of human gallbladder
Immunohistochemical staining of human gallbladder shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_5_4_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/38_D11_1_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/40_D11_1_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuronal cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_B_7_5.jpg
Normal Tissue
Figure 6 Colon
Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Peripheral nerve/ganglion
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_9_3.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_9_4.jpg
Normal Tissue
Figure 8 Kidney
Cells in tubules
Staining:
High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_8_5.jpg
Normal Tissue
Figure 9 Testis
Leydig cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_5_6.jpg
Normal Tissue
Figure 10 Placenta
Trophoblastic cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_1_7.jpg
Normal Tissue
Figure 11 Lymph node
Non-germinal center cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_9_8.jpg
RNA Expression
Figure 12 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 12 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132109-TRIM21
❮
❯
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human TRIM21
- Species Reactivity
- Human
- Applications
- Western Blot
- Conjugate
- Unconjugated, FITC
- Related Disease
- Lupus Erythematosus and Sjogren Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Tripartite Motif Containing 21; Sjogren Syndrome Antigen A1 (52kDa, Ribonucleoprotein Autoantigen SS-A/Ro); 52 KDa Ribonucleoprotein Autoantigen Ro/SS-A; RING-Type E3 Ubiquitin Transferase TRIM21; Tripartite Motif-Containing Protein 21; Sjoegren Syndrome Type A Antigen; RING Finger Protein 81; 52 KDa Ro Protein; Ro(SS-A); RNF81
- Gene ID
- 6737
- UniProt ID
- P19474
- Sequence Similarities
- Belongs to the TRIM/RBCC family.
- Cellular Localization
- Cytoplasm
Cytoplasmic vesicle, autophagosome
Nucleus
Cytoplasm, P-body
Cytoplasm, Stress granule
- Post Translation Modifications
- Autoubiquitinated; does not lead to its proteasomal degradation.
Deubiquitinated by USP4; leading to its stabilization.
(P19474-RO52_HUMAN)
Ubiquitination at Lys260 (NX_P19474 [NX_P19474-1])
Modification sites at PhosphoSitePlus (P19474)
Glycosylation from GlyGen (P19474) 1 site, 1 O-linked glycan (1 site)
- Function
- Plays a role in the regulation of the cell cycle progression (PubMed:16880511).
Enhances the decapping activity of DCP2 (PubMed:18361920).
Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "TRIM21"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1189z | Mouse Anti-TRIM21 Recombinant Antibody (clone 20C4) | WB, ELISA | Mouse IgG1 |
| FAMAB-0007JF | Chicken Anti-TRIM21 Recombinant Antibody (clone R2E5) | WB, Neut, Inhib, FuncS, IHC | |
| VS3-QX1165 | Mouse Anti-TRIM21 Recombinant Antibody (clone 5B9-B9-H8) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0007JF-F(E) | Chicken Anti-TRIM21 Recombinant Antibody (clone R2E5); Fab Fragment | IB, WB, ELISA, FuncS | Chicken Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0007JF-S(P) | Chicken Anti-TRIM21 Recombinant Antibody (clone R2E5); scFv Fragment | IB, WB, ELISA, FuncS | Chicken scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2352 | Anti-TRIM21 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7517 | Anti-Human TRIM21 Immunohistochemistry Kit | IHC |
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