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    Rabbit Anti-TRIM21 Recombinant Antibody (VS3-FY2906) (CAT#: VS3-FY2906)

    The anti-TRIM21 product is a recombinant rabbit monoclonal antibody that binds to human TRIM21 protein. This monoclonal antibody is suitable for conducting research on Lupus Erythematosus and Sjogren Syndrome. The optimal dilution for this antibody is Western Blot (1/500-1/1000).

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line HUVEC TERT2
    Figure 1 IF staining of human cell line HUVEC TERT2
    (Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/1752_A4_4_cr581104495f16e_selected.jpg
    Figure 2 IHC staining of human gallbladder
    Figure 2 IHC staining of human gallbladder
    (Immunohistochemical staining of human gallbladder shows strong cytoplasmic positivity in glandular cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_5_4_selected.jpg
    Figure 3 IF staining of human cell line U-2 OS
    Figure 3 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/38_D11_1_red_green.jpg
    Figure 4 IF staining of human cell line U-251 MG
    Figure 4 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/40_D11_1_red_green.jpg
    Normal Tissue
    Figure 5 Cerebral cortex
    Figure 5 Cerebral cortex
    (Neuronal cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_B_7_5.jpg
    Figure 6 Colon
    Figure 6 Colon
    (Glandular cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Peripheral nerve/ganglion
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_9_3.jpg
    Figure 7 Liver
    Figure 7 Liver
    (Cholangiocytes
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_9_4.jpg
    Figure 8 Kidney
    Figure 8 Kidney
    (Cells in tubules
    Staining:

    High

    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_8_5.jpg
    Figure 9 Testis
    Figure 9 Testis
    (Leydig cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_5_6.jpg
    Figure 10 Placenta
    Figure 10 Placenta
    (Trophoblastic cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_1_7.jpg
    Figure 11 Lymph node
    Figure 11 Lymph node
    (Non-germinal center cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5673/20093_A_9_8.jpg
    RNA Expression
    Figure 12 RNA cell line category: Low cell line specificity
    Figure 12 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * https://v21.proteinatlas.org/ENSG00000132109-TRIM21
    Figure 12 RNA cell line category: Low cell line specificity
    Figure 12 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132109-TRIM21

    Specifications

    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Human TRIM21
    • Species Reactivity
    • Human
    • Applications
    • Western Blot
    • Conjugate
    • Unconjugated, FITC
    • Related Disease
    • Lupus Erythematosus and Sjogren Syndrome

    Product Property

    • Clonality
    • Monoclonal Antibody
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • Western Blot: 1/500-1/1000

    Target

    • Alternative Names
    • Tripartite Motif Containing 21; Sjogren Syndrome Antigen A1 (52kDa, Ribonucleoprotein Autoantigen SS-A/Ro); 52 KDa Ribonucleoprotein Autoantigen Ro/SS-A; RING-Type E3 Ubiquitin Transferase TRIM21; Tripartite Motif-Containing Protein 21; Sjoegren Syndrome Type A Antigen; RING Finger Protein 81; 52 KDa Ro Protein; Ro(SS-A); RNF81
    • Sequence Similarities
    • Belongs to the TRIM/RBCC family.
    • Cellular Localization
    • Cytoplasm
      Cytoplasmic vesicle, autophagosome
      Nucleus
      Cytoplasm, P-body
      Cytoplasm, Stress granule
    • Post Translation Modifications
    • Autoubiquitinated; does not lead to its proteasomal degradation.
      Deubiquitinated by USP4; leading to its stabilization.
      (P19474-RO52_HUMAN)
      Ubiquitination at Lys260 (NX_P19474 [NX_P19474-1])
      Modification sites at PhosphoSitePlus (P19474)
      Glycosylation from GlyGen (P19474) 1 site, 1 O-linked glycan (1 site)
    • Function
    • Plays a role in the regulation of the cell cycle progression (PubMed:16880511).
      Enhances the decapping activity of DCP2 (PubMed:18361920).
      Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules.

    Recommended Products

    Secondary Antibody

    Isotype Control

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "TRIM21"

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    IgG Antibody Products Fab Antibody Products ScFv Antibody Products IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
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    MOB-1189z Mouse Anti-TRIM21 Recombinant Antibody (clone 20C4) WB, ELISA Mouse IgG1
    FAMAB-0007JF Chicken Anti-TRIM21 Recombinant Antibody (clone R2E5) WB, Neut, Inhib, FuncS, IHC
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