Mouse Anti-TSPAN15 Recombinant Antibody (clone VS0724W4)
CAT#: VS-0724-FY19
This is a mouse antibody that specially recognizes human TSPAN15. VS0724W4 has been reported to partially inhibit cleavage of VE-cadherin by ADAM10 in a cell-based cleavage assay. The antibody contact site is primarily located in the loop formed by the C198-C219 disulfide bond, which also contains a small helical segment.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human TSPAN15
- Species Reactivity
- Human
- Clone
- VS0724W4
- Applications
- Immunoprecipitation
- Related Disease
- Femoral Vein Thrombophlebitis
Product Property
- Clonality
- Monoclonal Antibody
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Tetraspanin 15; Transmembrane 4 Superfamily Member 15; Tetraspan NET-7; Tspan-15; TM4SF15; NET7
- Gene ID
- 23555
- UniProt ID
- O95858
- Long Name
- Tetraspanin 15
- Sequence Similarities
- Belongs to the tetraspanin (TM4SF) family.
- Cellular Localization
- Cell membrane; Multi-pass membrane protein
- Post Translation Modifications
- Palmitoylated
Glycosylation at Asn118, Asn189, and Asn230
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites
- Protein Refseq
- XP_005269723.1; XP_011537864.1; XP_011537865.1; XP_016871499.1; XP_047280886.1
- Function
- This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity.
Different TspanC8/ADAM10 complexes have distinct substrates.
Promotes ADAM10-mediated cleavage of CDH2.
Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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