Rabbit Anti-UCHL3 Recombinant Antibody (clone R07-1K4) (CAT#: VS3-XY3534)
This is a recombinant rabbit antibody that specifically recognizes human UCHL3 (Ubiquitin C-terminal hydrolase L3), which may be involved in working memory. The antibody also has cross-reactivity against mouse and rat UCHL3. It has been reported for use in Western Blot. The recommended dilutions of Western Blot is 1/500-1/1000.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19678/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19678/if_selected.jpg
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows cytoplasmic positivity in cells of seminiferus ducts.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19678/ihc_selected.jpg
(Immunohistochemical staining of human testis shows cytoplasmic positivity in cells of seminiferus ducts.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19678/ihc_selected.jpg
Figure 3 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37208/90536_A_9_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37208/90536_A_9_5.jpg
Figure 4 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000118939-UCHL3
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000118939-UCHL3
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat UCHL3
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R07-1K4
- Applications
- WB
- Related Disease
- Machado-Joseph Disease; Autosomal Dominant Cerebellar Ataxia
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- UCH-L3
- Gene ID
- 7347
- UniProt ID
- P15374
- Long Name
- Ubiquitin C-terminal hydrolase L3
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Ubiquitination at Lys121 (NX_P15374 [NX_P15374-1])
Modification sites at PhosphoSitePlus (P15374)
Glycosylation from GlyGen (P15374) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011533515.1
- Function
- Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins.
Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8.
Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains.
Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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